Luis Felipe Reyes, Colombia

Universidad de La Sabana Infectious Diseases Department

Poster Author Of 3 e-Posters

Online Abstracts Clinical Sciences - Disease Burden in Infants, Children/Youth, and Adults B2 Disease Burden in Infants, Children/Youth, and Adults

Presenter Of 2 Presentations

EVOLUTION OF INVASIVE PNEUMOCOCCAL DISEASE (IPD) BURDEN AND THE POTENTIAL EFFECT OF UNIVERSAL PNEUMOCOCCAL VACCINATION IN BOGOTÁ, COLOMBIA (ID 740)

Abstract

Background

IPD is the leading cause of infectious death worldwide. The universal pneumococcal vaccine in children has reduced IPD burden in several countries around the world. Importantly, after vaccine introduction, different pneumococcal serotypes are more frequently identified. However, in Bogotá-Colombia, there are scares data about the effect of the pneumococcal vaccine and its burden. Therefore, this study aims to provide novel data

Methods

This is a retrospective analysis of the pneumococcal reports of a surveillance program during the last 15 years in Bogotá, Colombia. S. pneumoniae were identified in each hospital and then characterized and serotyped in a governamental centralized laboratory. Descriptive statistics were used

Results

A total of 2605 cases were analyzed. Most common serotypes were 14 (7.11%), 1 (3.13%) 6A and 6B (2.71%) before 2010. Between 2011-2019, the most common serotypes changed to 19A (14.9%), 3 (8.06%) and 6C (3.86%) (Figure-1). Importantly, there was no change in the incidence of invasive pneumococcal disease throughout the study

figure 1_burden.jpg

Conclusions

Most common serotypes were 14 (7.11%), 1 (3.13%) 6A and 6B (2.71%) before 2010. Between 2011-2019, the most common serotypes changed to 19A (14.9%), 3 (8.06%) and 6C (3.86%) (Figure-1). Importantly, there was no change in the incidence of invasive pneumococcal disease throughout the study

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A MODEL TO PREDICT THE POTENTIAL ROLE OF NEW ANTI-PNEUMOCOCCAL VACCINES IN BOGOTÁ, COLOMBIA (ID 739)

Abstract

Background

Anti-pneumococcal vaccines are the most effective strategy to prevent pneumococcal disease. However, the pneumococcal burden continues to be a remarkable problem worldwide. Thus, new conjugated vaccines are under development. Through the analysis of the prevalence of pneumococcal serotypes between 2005-2019, we aim to determine the theorical effect of these vaccines in Bogotá, Colombia.

Methods

This is a retrospective analysis of patients reported to a surveillance program due to invasive pneumococcal disease, between 2005 and 2019. We compared the potential serotype coverage of PCV10, PCV13, PCV15, PCV20 by age groups to determine the possible role of these vaccines in Bogotá, Colombia.

Results

A total of 2605 patients were included. In the group of children ˂5 years, PCV10 had serotype coverage of 9%, PCV13 of 27.8%, PCV15 of 28.2%, and PCV20 of 30%. In Adults ˃18 years, PCV10 covered was 11.8%, PCV13 of 26.6%, PCV15 of 27.7%, and PCV20 of 32.7% (Figure-1). Additionally, in adults ˃65 years, PCV10 covered was 10.2%, PCV13 of 26%, PCV15 of 27.4%, and PCV20 of 34%.

figure 2_vaccines.jpg

Conclusions

According to the most prevalent serotypes in our city, the usage of new vaccines may prevent some episodes of IPD in Bogotá, Colombia. However, further clinical, epidemiological and pharmacoeconomical studies should be performed

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Author Of 5 Presentations

STREPTOCOCCUS PNEUMONIAE SEROTYPES 19A AND 3 ARE THE MAIN CAUSE OF INVASIVE PNEUMOCOCCAL DISEASE IN ADULTS IN BOGOTÁ, COLOMBIA (ID 707)

Abstract

Background

Incidence of Invasive pneumococcal disease (IPD) depends on numerous factors, including vaccine undertake, geographic location, and serotype prevalence. There is limited data about the incidence of Streptococcus pneumoniae (Spn), serotype distribution, and clinical characteristics of adults hospitalized due to IPD in Colombia. Thus, this study will attempt to bridge this gap in the literature.

Methods

This is an observational, retrospective, citywide study conducted between 2012 and 2019 in Bogotá, Colombia. We analyzed, reported positive cases of IPD. Importantly, Bogotá represents approximately 75% of the Colombian population. Strains were isolated in each hospital and typified in a centralized laboratory. The objectives included assessment of Spn serotype distribution, clinical diagnosis, mortality, ICU admission, and need for mechanical ventilation.

Results

A total of 314 patients with IPD were included, 54.8% male. The leading cause of IPD was pneumonia (33%), followed by meningitis and sepsis. The most prevalent serotypes were 19A (13.1%) and 3 (12.4%). The overall hospital mortality was 30%. Moreover, 65.6% were admitted to the ICU, 44.9% required invasive mechanical ventilation, and 5.1% non- invasive mechanical ventilation.

Conclusions

Pneumococcal pneumonia continues to be the most prevalent cause of IPD. Serotypes 19A and 3 are the leading cause of IPD in Colombian adults.

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PATIENTS WITH MENINGITIS DUE TO STREPTOCOCCUS PNEUMONIAE ALSO MIGHT DEVELOP MAJOR ADVERSE CARDIOVASCULAR EVENTS (MACE) (ID 716)

Abstract

Background

Streptococcus pneumoniae (Spn) is the leading cause of community-acquired pneumonia (CAP) and bacterial meningitis in adults. Recent studies have shown that up to 30% of patients admitted due to pneumococcal CAP develop major adverse cardiovascular events (MACE, i.e., new/worsening arrhythmia, new/worsening heart failure, and myocardial infarction). However, it is unknown whether MACE could also be identified in patients with pneumococcal meningitis.

Methods

In this observational, multicentric retrospective study. We analyzed medical records from adult patients with invasive pneumococcal disease (IPD) reported in a surveillance program across all hospitals in Bogotá, Colombia, between 2012 and 2019. Pneumococcal meningitis was confirmed by the identification of Spn in blood cultures and/or cerebrospinal fluid cultures and clinical presentation. Adverse cardiac outcomes were blinded evaluated in each case.

Results

From a total of 314 patients with microbiological Spn isolation, 19.7% (62/314) were diagnosed with pneumococcal meningitis. Out of the 62 patients evaluated, 10 (16%) developed MACE, 8.1% (5) new/worsening heart failure, 6.5% (4) new/worsening arrhythmia, and 3.2% (2) myocardial infarction.

Conclusions

To our knowledge, this is the first clinical study showing that patients with pneumococcal meningitis could be at risk of MACE as reported in pneumococcal CAP. Further studies are needed to characterize patients at risk better.

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A MODEL TO PREDICT THE POTENTIAL ROLE OF NEW ANTI-PNEUMOCOCCAL VACCINES IN BOGOTÁ, COLOMBIA (ID 739)

Abstract

Background

Anti-pneumococcal vaccines are the most effective strategy to prevent pneumococcal disease. However, the pneumococcal burden continues to be a remarkable problem worldwide. Thus, new conjugated vaccines are under development. Through the analysis of the prevalence of pneumococcal serotypes between 2005-2019, we aim to determine the theorical effect of these vaccines in Bogotá, Colombia.

Methods

This is a retrospective analysis of patients reported to a surveillance program due to invasive pneumococcal disease, between 2005 and 2019. We compared the potential serotype coverage of PCV10, PCV13, PCV15, PCV20 by age groups to determine the possible role of these vaccines in Bogotá, Colombia.

Results

A total of 2605 patients were included. In the group of children ˂5 years, PCV10 had serotype coverage of 9%, PCV13 of 27.8%, PCV15 of 28.2%, and PCV20 of 30%. In Adults ˃18 years, PCV10 covered was 11.8%, PCV13 of 26.6%, PCV15 of 27.7%, and PCV20 of 32.7% (Figure-1). Additionally, in adults ˃65 years, PCV10 covered was 10.2%, PCV13 of 26%, PCV15 of 27.4%, and PCV20 of 34%.

figure 2_vaccines.jpg

Conclusions

According to the most prevalent serotypes in our city, the usage of new vaccines may prevent some episodes of IPD in Bogotá, Colombia. However, further clinical, epidemiological and pharmacoeconomical studies should be performed

Hide

EVOLUTION OF INVASIVE PNEUMOCOCCAL DISEASE (IPD) BURDEN AND THE POTENTIAL EFFECT OF UNIVERSAL PNEUMOCOCCAL VACCINATION IN BOGOTÁ, COLOMBIA (ID 740)

Abstract

Background

IPD is the leading cause of infectious death worldwide. The universal pneumococcal vaccine in children has reduced IPD burden in several countries around the world. Importantly, after vaccine introduction, different pneumococcal serotypes are more frequently identified. However, in Bogotá-Colombia, there are scares data about the effect of the pneumococcal vaccine and its burden. Therefore, this study aims to provide novel data

Methods

This is a retrospective analysis of the pneumococcal reports of a surveillance program during the last 15 years in Bogotá, Colombia. S. pneumoniae were identified in each hospital and then characterized and serotyped in a governamental centralized laboratory. Descriptive statistics were used

Results

A total of 2605 cases were analyzed. Most common serotypes were 14 (7.11%), 1 (3.13%) 6A and 6B (2.71%) before 2010. Between 2011-2019, the most common serotypes changed to 19A (14.9%), 3 (8.06%) and 6C (3.86%) (Figure-1). Importantly, there was no change in the incidence of invasive pneumococcal disease throughout the study

figure 1_burden.jpg

Conclusions

Most common serotypes were 14 (7.11%), 1 (3.13%) 6A and 6B (2.71%) before 2010. Between 2011-2019, the most common serotypes changed to 19A (14.9%), 3 (8.06%) and 6C (3.86%) (Figure-1). Importantly, there was no change in the incidence of invasive pneumococcal disease throughout the study

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MAJOR ADVERSE CARDIOVASCULAR EVENTS DURING INVASIVE PNEUMOCOCCAL DISEASE ARE SEROTYPE DEPENDENT (ID 700)

Abstract

Background

Worldwide up to 30% of patients admitted to hospitals due to community-acquired pneumonia (CAP) develop major-adverse-cardiovascular events (MACE). Importantly, patients who develop MACE have a higher risk of dying during acute hospitalization and up to 10 years thereafter. Streptococcus pneumoniae (Spn) is the only etiological agent linked independently to MACE. However, there is no data regarding which Spn serotype is more associated with MACE in humans.

Methods

This is an observational, multicentric, retrospective cohort study conducted through the Health Secretary of Bogotá (HSB), Colombia. All patients with the diagnosis of invasive pneumococcal disease (IPD), reported in Bogota to the HIB between 2012 and 2019 were included. Serotyping was carryout at the HIB. MACE were defined as new/worsening heart failure, new/worsening arrhythmias, and/or myocardial infarctions. A multivariate analysis was performed.

Results

A total of 314 patients with IPD were included. 22.6% (71/314) developed MACE. As previously described, patients were older and with more comorbid conditions. However, patients with Spn serotype 3 were independently associated with MACE after adjusting for disease severity and comorbid conditions (OR 2.20; 95%CI 1.02, 4.76).

Conclusions

In patients admitted due to IPD, Spn serotype 3 is independently associated with MACE. Further molecular characterization and experiments are needed to prove causality.

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