Edwin Silva,

Author Of 2 Presentations

A MODEL TO PREDICT THE POTENTIAL ROLE OF NEW ANTI-PNEUMOCOCCAL VACCINES IN BOGOTÁ, COLOMBIA (ID 739)

Abstract

Background

Anti-pneumococcal vaccines are the most effective strategy to prevent pneumococcal disease. However, the pneumococcal burden continues to be a remarkable problem worldwide. Thus, new conjugated vaccines are under development. Through the analysis of the prevalence of pneumococcal serotypes between 2005-2019, we aim to determine the theorical effect of these vaccines in Bogotá, Colombia.

Methods

This is a retrospective analysis of patients reported to a surveillance program due to invasive pneumococcal disease, between 2005 and 2019. We compared the potential serotype coverage of PCV10, PCV13, PCV15, PCV20 by age groups to determine the possible role of these vaccines in Bogotá, Colombia.

Results

A total of 2605 patients were included. In the group of children ˂5 years, PCV10 had serotype coverage of 9%, PCV13 of 27.8%, PCV15 of 28.2%, and PCV20 of 30%. In Adults ˃18 years, PCV10 covered was 11.8%, PCV13 of 26.6%, PCV15 of 27.7%, and PCV20 of 32.7% (Figure-1). Additionally, in adults ˃65 years, PCV10 covered was 10.2%, PCV13 of 26%, PCV15 of 27.4%, and PCV20 of 34%.

figure 2_vaccines.jpg

Conclusions

According to the most prevalent serotypes in our city, the usage of new vaccines may prevent some episodes of IPD in Bogotá, Colombia. However, further clinical, epidemiological and pharmacoeconomical studies should be performed

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EVOLUTION OF INVASIVE PNEUMOCOCCAL DISEASE (IPD) BURDEN AND THE POTENTIAL EFFECT OF UNIVERSAL PNEUMOCOCCAL VACCINATION IN BOGOTÁ, COLOMBIA (ID 740)

Abstract

Background

IPD is the leading cause of infectious death worldwide. The universal pneumococcal vaccine in children has reduced IPD burden in several countries around the world. Importantly, after vaccine introduction, different pneumococcal serotypes are more frequently identified. However, in Bogotá-Colombia, there are scares data about the effect of the pneumococcal vaccine and its burden. Therefore, this study aims to provide novel data

Methods

This is a retrospective analysis of the pneumococcal reports of a surveillance program during the last 15 years in Bogotá, Colombia. S. pneumoniae were identified in each hospital and then characterized and serotyped in a governamental centralized laboratory. Descriptive statistics were used

Results

A total of 2605 cases were analyzed. Most common serotypes were 14 (7.11%), 1 (3.13%) 6A and 6B (2.71%) before 2010. Between 2011-2019, the most common serotypes changed to 19A (14.9%), 3 (8.06%) and 6C (3.86%) (Figure-1). Importantly, there was no change in the incidence of invasive pneumococcal disease throughout the study

figure 1_burden.jpg

Conclusions

Most common serotypes were 14 (7.11%), 1 (3.13%) 6A and 6B (2.71%) before 2010. Between 2011-2019, the most common serotypes changed to 19A (14.9%), 3 (8.06%) and 6C (3.86%) (Figure-1). Importantly, there was no change in the incidence of invasive pneumococcal disease throughout the study

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