MAJOR ADVERSE CARDIOVASCULAR EVENTS DURING INVASIVE PNEUMOCOCCAL DISEASE ARE SEROTYPE DEPENDENT
Worldwide up to 30% of patients admitted to hospitals due to community-acquired pneumonia (CAP) develop major-adverse-cardiovascular events (MACE). Importantly, patients who develop MACE have a higher risk of dying during acute hospitalization and up to 10 years thereafter. Streptococcus pneumoniae (Spn) is the only etiological agent linked independently to MACE. However, there is no data regarding which Spn serotype is more associated with MACE in humans.
This is an observational, multicentric, retrospective cohort study conducted through the Health Secretary of Bogotá (HSB), Colombia. All patients with the diagnosis of invasive pneumococcal disease (IPD), reported in Bogota to the HIB between 2012 and 2019 were included. Serotyping was carryout at the HIB. MACE were defined as new/worsening heart failure, new/worsening arrhythmias, and/or myocardial infarctions. A multivariate analysis was performed.
A total of 314 patients with IPD were included. 22.6% (71/314) developed MACE. As previously described, patients were older and with more comorbid conditions. However, patients with Spn serotype 3 were independently associated with MACE after adjusting for disease severity and comorbid conditions (OR 2.20; 95%CI 1.02, 4.76).
In patients admitted due to IPD, Spn serotype 3 is independently associated with MACE. Further molecular characterization and experiments are needed to prove causality.