Jose I. Nuñez Varela, Colombia

Universidad de La Sabana Infectious Diseases Department

Author Of 1 Presentation

PATIENTS WITH MENINGITIS DUE TO STREPTOCOCCUS PNEUMONIAE ALSO MIGHT DEVELOP MAJOR ADVERSE CARDIOVASCULAR EVENTS (MACE) (ID 716)

Abstract

Background

Streptococcus pneumoniae (Spn) is the leading cause of community-acquired pneumonia (CAP) and bacterial meningitis in adults. Recent studies have shown that up to 30% of patients admitted due to pneumococcal CAP develop major adverse cardiovascular events (MACE, i.e., new/worsening arrhythmia, new/worsening heart failure, and myocardial infarction). However, it is unknown whether MACE could also be identified in patients with pneumococcal meningitis.

Methods

In this observational, multicentric retrospective study. We analyzed medical records from adult patients with invasive pneumococcal disease (IPD) reported in a surveillance program across all hospitals in Bogotá, Colombia, between 2012 and 2019. Pneumococcal meningitis was confirmed by the identification of Spn in blood cultures and/or cerebrospinal fluid cultures and clinical presentation. Adverse cardiac outcomes were blinded evaluated in each case.

Results

From a total of 314 patients with microbiological Spn isolation, 19.7% (62/314) were diagnosed with pneumococcal meningitis. Out of the 62 patients evaluated, 10 (16%) developed MACE, 8.1% (5) new/worsening heart failure, 6.5% (4) new/worsening arrhythmia, and 3.2% (2) myocardial infarction.

Conclusions

To our knowledge, this is the first clinical study showing that patients with pneumococcal meningitis could be at risk of MACE as reported in pneumococcal CAP. Further studies are needed to characterize patients at risk better.

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