Beth Temple, Australia

Menzies School of Health Research Global Health

Author Of 10 Presentations

 Conference Calendar

COMPARISON OF A 2+1 AND 3+0 SCHEDULE OF PCV10 IN VIETNAM (ID 1035)

Session Name
Vaccines - Pneumococcal Vaccines Development
Presenter
Authors

IMMUNOGENICITY OF A SINGLE DOSE OF PCV10 GIVEN AT 18 MONTHS OF AGE AND IMPACT ON NASOPHARYNGEAL CARRIAGE IN VIETNAMESE CHILDREN (ID 735)

Session Name
Vaccines - Pneumococcal Vaccines Development
Presenter
Authors

PROGRESS IN THE RANDOMISED CONTROLLED TRIAL "TRIAL OF SIMPLIFIED PNEUMOCOCCAL VACCINATION IN VIETNAM II: THE HERD IMMUNITY APPROACH". (ID 864)

Session Name
Vaccines - Pneumococcal Vaccines Development
Presenter
Authors

COMPARISON OF IMMUNOGENICITY OF TEN- AND THIRTEEN-VALENT PNEUMOCOCCAL CONJUGATE VACCINES – A SYSTEMATIC REVIEW AND NETWORK META-ANALYSIS (ID 567)

Session Name
Population Sciences - Epidemiology, Economics, and Mathematical Modelling
Presenter
Authors

Abstract

Background

Streptococcus pneumoniae causes substantial morbidity and mortality globally, with serotype-specific disease burden varying geographically. Currently there are two widely used pneumococcal conjugate vaccines (PCV). Evidence is limited regarding their comparative serotype-specific immunogenicity and efficacy.

Methods

We conducted a systematic-review and network meta-analysis of studies in which the immunogenicity of PCVs was directly compared in head-to-head randomised trials. Network meta-analysis incorporates both direct pair-wise comparisons and indirect comparisons (e.g. PCV10 vs PCV7, and PCV13 vs PCV7) thereby increasing overall statistical precision for the main comparison of interest (PCV10 vs PCV13). The difference in immunogenicity, as measured by geometric mean ratio (GMR), was examined by serotype.

Results

27 trials were included in the network meta-analysis, 4 directly comparing PCV10 and PCV13, 7 comparing PCV7 and PCV10, and 16 comparing PCV7 and PCV13. For the 10 common serotypes, immunogenicity at 1 month after the primary vaccination series was higher for PCV13 for 7 serotypes, with GMRs ranging from 1.18 to 2.50. In contrast, serotype 5, 18C and 19F favoured PCV10. Similar results were observed post-booster dose except for serotype 5 and 7F.

Conclusions

Variation in serotype-specific immunogenicity exists between PCV10 and PCV13, indicating that further investigation into whether this translates to heterogeneity in protection is needed.

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IMMUNOGENICITY OF A SINGLE DOSE OF PCV10 OR PCV13 AT 2 MONTHS OF AGE IN VIETNAM (ID 1007)

Session Name
Vaccines - Pneumococcal Vaccines Development
Presenter
Authors

Abstract

Background

A 1+1 pneumococcal conjugate vaccine (PCV) schedule would increase its affordability for low and middle-income countries. The Vietnam Pneumococcal Trial II includes infants randomised to receive a 1+1 schedule of PCV10 or PCV13 at 2 and 12 months of age. This study measured the immunogenicity of a single dose of either PCV given at 2 months of age.

Methods

Serotype-specific IgG was measured at 3 and 12 months of age in PCV-vaccinated and unvaccinated controls using a WHO ELISA method.

Results

At 3 months, both vaccinated groups had higher antibody levels than controls for 7/10 serotypes (all except 6B, 14, 23F). The PCV10 group had higher antibody levels than the PCV13 group for 5/10 serotypes. Similar results were seen at 12 months, with higher antibody levels for all serotypes in the PCV10 group and 8/10 serotypes (all except 6V, 23F) in the PCV13 group compared with controls and higher antibody levels in the PCV10 than the PCV13 group for 7/10 serotypes.

Conclusions

A single dose of PCV in infancy is immunogenic and likely to provide some direct protection until the time of the booster dose. There may be a difference in the degree of protection offered by different PCVs.

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CO-ADMINISTRATION OF 10-VALENT PNEUMOCOCCAL CONJUGATE VACCINE AND MEASLES VACCINE DOES NOT IMPACT ON THE IMMUNOGENICITY OF MEASLES VACCINE (ID 727)

Session Name
Basic Sciences - Immunology, Pathogenesis, and Host-pathogen Interactions
Presenter
Authors

STUDY PARTICIPANT WITHDRAWALS: LESSONS LEARNT FROM A VACCINE TRIAL IN INFANTS IN HO CHI MINH CITY, VIETNAM (ID 1105)

Session Name
Vaccines - Pneumococcal Vaccines Development
Presenter
Authors

Abstract

Background

Subject recruitment and retention are crucial factors contributing to the success of clinical trials. We describe the experience from a clinical trial of
pneumococcal conjugate vaccines currently underway in Ho Chi Minh City.

Methods

Subject recruitment and retention are crucial factors contributing to the success of clinical trials. We describe the experience from a clinical trial of
pneumococcal conjugate vaccines currently underway in Ho Chi Minh City.

Results

2,501 subjects were recruited at 2 months of age. To date 1,612 subjects have completed their final 24 month visit. The last 24 month visit is due in May 2020. We have a current withdrawal rate of 7.8%. The most common reason for withdrawal is moving outside the study area. Withdrawal rates and reasons by study group will be presented at the conference

Conclusions

Recruiting subjects who intend to remain in the study area is a challenge for clinical trials involving follow up of children over a number of years. Involving staff from subjects' local health clinics helps to keep the withdrawal rate down.

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DISEASE FEATURES OF VIETNAMMESE INFANTS FROM HOSPITAL ADMISSIONS OF A PNEUMOCOCCAL VACCINE PHASE 3 CLINICAL TRIAL (ID 741)

Session Name
Vaccines - Impact of Vaccine programs and Serotype Replacement
Presenter
Authors

INCREASED PCV10 IMMUNOGENICITY FOLLOWING A TWO-DOSE PRIMARY SERIES SEPARATED BY 4 MONTHS COMPARED WITH 2 MONTHS IN VIETNAMESE INFANTS (ID 963)

Session Name
Vaccines - Pneumococcal Vaccines Development
Presenter
Authors

IMPACT OF A SINGLE DOSE OF PCV10 OR PCV13 ON NASOPHARYNGEAL PNEUMOCOCCAL CARRIAGE IN VIETNAMESE CHILDREN DURING THE FIRST YEAR OF LIFE (ID 696)

Session Name
Vaccines - Impact of Vaccine programs and Serotype Replacement
Presenter
Authors

Abstract

Background

Reduced-dose schedules of pneumococcal conjugate vaccine (PCV) could increase the accessibility and use of PCV in low and middle-income countries.

Methods

Groups within the Vietnam Pneumococcal Trial II receive PCV10 and PCV13 in a 1+1 schedule at 2 and 12 months of age, or no vaccine. Nasopharyngeal swabs were collected at 6 and 12 months of age to show the impact of the 2-month dose on pneumococcal carriage.

Results

Based on analysis to date of 1152 of 3200 swabs, vaccine-type carriage was low. In unvaccinated participants, PCV10 and PCV13-type carriage were 5.1% and 10.4% at 6 months, and 8.3% and 12.0% at 12 months, respectively. A dose of PCV10 transiently reduced vaccine-type carriage at 6 months of age (3/178 [1.7%] versus 18/355 [5.1%]).

Conclusions

With the exception of the PCV10 group at 6 months of age, both vaccine-type and non-vaccine-type carriage rates were similar among PCV10-vaccinated participants, PCV13-vaccinated participants and unvaccinated controls at 6 and 12 months of age. Based on preliminary data, a single dose of PCV at 2 months of age does not appear to reduce pneumococcal carriage during the first year of life in this population.

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Presenter of 1 Presentation

 Conference Calendar

COMPARISON OF A 2+1 AND 3+0 SCHEDULE OF PCV10 IN VIETNAM (ID 1035)

Session Name
Vaccines - Pneumococcal Vaccines Development
Presenter
Authors