Trong Toan Nguyen, Viet Nam
Pasteur Institute of Ho Chi Minh City Department of Disease Control and PreventionAuthor Of 7 Presentations
INCREASED PCV10 IMMUNOGENICITY FOLLOWING A TWO-DOSE PRIMARY SERIES SEPARATED BY 4 MONTHS COMPARED WITH 2 MONTHS IN VIETNAMESE INFANTS (ID 963)
- Paul V. Licciardi, Australia
- Beth Temple, Australia
- Dai V. Trang, Australia
- Trong Toan Nguyen, Viet Nam
- Uyen Y. Doan, Viet Nam
- Cattram D. Nguyen, Australia
- Thanh V. Phan, Viet Nam
- Kathryn Bright, Australia
- Rachel A. Marimla, Australia
- Anne Balloch, Australia
- Tran Ngoc Huu, Viet Nam
- Kim E. Mulholland, Australia
COMPARISON OF A 2+1 AND 3+0 SCHEDULE OF PCV10 IN VIETNAM (ID 1035)
- Beth Temple, Australia
- Paul V. Licciardi, Australia
- Vo Thi Trang Dai, Viet Nam
- Trong Toan Nguyen, Viet Nam
- Doan Y. Uyen, Viet Nam
- Cattram D. Nguyen, Australia
- Thanh V. Phan, Viet Nam
- Hoan Thi Pham, Viet Nam
- Kathryn Bright, Australia
- Rachel A. Marimla, Australia
- Monica L. Nation, Australia
- Belinda D. Ortika, Australia
- Catherine Satzke, Australia
- Heidi Smith-Vaughan, Australia
- Anne Balloch, Australia
- Tran Ngoc Huu, Viet Nam
- Edward K. Mulholland,
CO-ADMINISTRATION OF 10-VALENT PNEUMOCOCCAL CONJUGATE VACCINE AND MEASLES VACCINE DOES NOT IMPACT ON THE IMMUNOGENICITY OF MEASLES VACCINE (ID 727)
PROGRESS IN THE RANDOMISED CONTROLLED TRIAL "TRIAL OF SIMPLIFIED PNEUMOCOCCAL VACCINATION IN VIETNAM II: THE HERD IMMUNITY APPROACH". (ID 864)
IMMUNOGENICITY OF A SINGLE DOSE OF PCV10 OR PCV13 AT 2 MONTHS OF AGE IN VIETNAM (ID 1007)
Abstract
Background
A 1+1 pneumococcal conjugate vaccine (PCV) schedule would increase its affordability for low and middle-income countries. The Vietnam Pneumococcal Trial II includes infants randomised to receive a 1+1 schedule of PCV10 or PCV13 at 2 and 12 months of age. This study measured the immunogenicity of a single dose of either PCV given at 2 months of age.
Methods
Serotype-specific IgG was measured at 3 and 12 months of age in PCV-vaccinated and unvaccinated controls using a WHO ELISA method.
Results
At 3 months, both vaccinated groups had higher antibody levels than controls for 7/10 serotypes (all except 6B, 14, 23F). The PCV10 group had higher antibody levels than the PCV13 group for 5/10 serotypes. Similar results were seen at 12 months, with higher antibody levels for all serotypes in the PCV10 group and 8/10 serotypes (all except 6V, 23F) in the PCV13 group compared with controls and higher antibody levels in the PCV10 than the PCV13 group for 7/10 serotypes.
Conclusions
A single dose of PCV in infancy is immunogenic and likely to provide some direct protection until the time of the booster dose. There may be a difference in the degree of protection offered by different PCVs.
STUDY PARTICIPANT WITHDRAWALS: LESSONS LEARNT FROM A VACCINE TRIAL IN INFANTS IN HO CHI MINH CITY, VIETNAM (ID 1105)
Abstract
Background
Subject recruitment and retention are crucial factors contributing to the success of clinical trials. We describe the experience from a clinical trial of
pneumococcal conjugate vaccines currently underway in Ho Chi Minh City.
Methods
Subject recruitment and retention are crucial factors contributing to the success of clinical trials. We describe the experience from a clinical trial of
pneumococcal conjugate vaccines currently underway in Ho Chi Minh City.
Results
2,501 subjects were recruited at 2 months of age. To date 1,612 subjects have completed their final 24 month visit. The last 24 month visit is due in May 2020. We have a current withdrawal rate of 7.8%. The most common reason for withdrawal is moving outside the study area. Withdrawal rates and reasons by study group will be presented at the conference
Conclusions
Recruiting subjects who intend to remain in the study area is a challenge for clinical trials involving follow up of children over a number of years. Involving staff from subjects' local health clinics helps to keep the withdrawal rate down.
IMMUNOGENICITY OF A SINGLE DOSE OF PCV10 GIVEN AT 18 MONTHS OF AGE AND IMPACT ON NASOPHARYNGEAL CARRIAGE IN VIETNAMESE CHILDREN (ID 735)
- Rachel A. Marimla, Australia
- Beth Temple, Australia
- Thi Trang Dai Vo, Viet Nam
- Thanh V. Phan, Viet Nam
- Trong Toan Nguyen, Viet Nam
- Leena Spry, Australia
- Monica L. Nation, Australia
- Belinda D. Ortika, Australia
- Doan Y. Uyen, Viet Nam
- Cattram D. Nguyen, Australia
- Kathryn Bright, Australia
- Anne Balloch, Australia
- Huu T. Ngoc, Viet Nam
- Kim E. Mulholland, Australia
- Catherine Satzke, Australia
- Paul V. Licciardi, Australia