IMPACT OF A SINGLE DOSE OF PCV10 OR PCV13 ON NASOPHARYNGEAL PNEUMOCOCCAL CARRIAGE IN VIETNAMESE CHILDREN DURING THE FIRST YEAR OF LIFE (ID 696)

Session Name
Vaccines - Impact of Vaccine programs and Serotype Replacement
Presenter
  • Hoan Thi Pham, Viet Nam
Authors
  • Hoan Thi Pham, Viet Nam
  • Beth Temple, Australia
  • Thi Trang Dai Vo, Viet Nam
  • Thanh V. Phan, Viet Nam
  • Loc Thuy Ho Nguyen, Viet Nam
  • Anh H.V Nguyen,
  • Belinda D. Ortika, Australia
  • Kathryn Bright, Australia
  • Catherine Satzke, Australia
  • Nevio D. Sarmento, Timor-Leste
  • Jemima Beissbarth, Australia
  • Heidi Smith-Vaughan, Australia
  • Thuong V. Nguyen, Viet Nam
  • Kim E. Mulholland, Australia

Abstract

Background

Reduced-dose schedules of pneumococcal conjugate vaccine (PCV) could increase the accessibility and use of PCV in low and middle-income countries.

Methods

Groups within the Vietnam Pneumococcal Trial II receive PCV10 and PCV13 in a 1+1 schedule at 2 and 12 months of age, or no vaccine. Nasopharyngeal swabs were collected at 6 and 12 months of age to show the impact of the 2-month dose on pneumococcal carriage.

Results

Based on analysis to date of 1152 of 3200 swabs, vaccine-type carriage was low. In unvaccinated participants, PCV10 and PCV13-type carriage were 5.1% and 10.4% at 6 months, and 8.3% and 12.0% at 12 months, respectively. A dose of PCV10 transiently reduced vaccine-type carriage at 6 months of age (3/178 [1.7%] versus 18/355 [5.1%]).

Conclusions

With the exception of the PCV10 group at 6 months of age, both vaccine-type and non-vaccine-type carriage rates were similar among PCV10-vaccinated participants, PCV13-vaccinated participants and unvaccinated controls at 6 and 12 months of age. Based on preliminary data, a single dose of PCV at 2 months of age does not appear to reduce pneumococcal carriage during the first year of life in this population.

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