Monica L. Nation, Australia

Murdoch Children's Research Institute Infection & Immunity

Author Of 8 Presentations

 Conference Calendar

DETERMINING THE PNEUMOCOCCAL CONJUGATE VACCINE COVERAGE REQUIRED FOR INDIRECT PROTECTION IN LAOS, MONGOLIA AND PAPUA NEW GUINEA (ID 851)

Session Name
Population Sciences - Epidemiology, Economics, and Mathematical Modelling
Presenter
Authors

PNEUMOCOCCAL CARRIAGE AND DENSITY IN MONGOLIAN CHILDREN WITH RADIOLOGICALLY-CONFIRMED PNEUMONIA AND HEALTHY CHILDREN FROM THE COMMUNITY. (ID 387)

Session Name
Vaccines - Impact of Vaccine programs and Serotype Replacement
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Authors

MONITORING PCV13 IMPACT USING NASOPHARYNGEAL CARRIAGE SURVEILLANCE AMONG CHILDREN WITH PNEUMONIA IN MONGOLIA (ID 965)

Session Name
Vaccines - Impact of Vaccine programs and Serotype Replacement
Presenter
Authors

Abstract

Background

In 2015, Mongolia was among the earliest countries in Asia to introduce PCV. To monitor the impact of PCV13 introduction, we commenced nasopharyngeal carriage surveillance among children with pneumonia 6 months prior to vaccine introduction.

Methods

We recruited children 2-59 months of age presenting with pneumonia to district hospitals and the national Maternal and Child Health hospital in two districts in Ulaanbaatar. Clinical and demographic data, vaccination status and nasopharyngeal swabs were collected. A random sample of swabs were selected for testing each month. Samples were examined by lytA qPCR, with positives serotyped by microarray.

Results

We recruited 4980 children and tested 983 children from November 2015 to April 2018. The median age was 1.27 and 25.81% of cases were vaccinated in the first and second year following PCV13 introduction, respectively. 474 and 48.22% had received antibiotics in the 48 hours before admission.

Conclusions

Following PCV13 introduction in Mongolia, the prevalence of pneumococcal carriage remained stable while the prevalence of PCV13-type carriage decreased among children with pneumonia. Reductions in PCV13 carriage likely correspond to reductions in disease due to PCV13 types, since carriage is a precursor for disease.

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IMMUNOGENICITY OF A SINGLE DOSE OF PCV10 GIVEN AT 18 MONTHS OF AGE AND IMPACT ON NASOPHARYNGEAL CARRIAGE IN VIETNAMESE CHILDREN (ID 735)

Session Name
Vaccines - Pneumococcal Vaccines Development
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Authors

COMPARISON OF A 2+1 AND 3+0 SCHEDULE OF PCV10 IN VIETNAM (ID 1035)

Session Name
Vaccines - Pneumococcal Vaccines Development
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Authors

LACK OF IMPACT OF PNEUMOCOCCAL CONJUGATE VACCINATION ON SEROTYPE-SPECIFIC PNEUMOCOCCAL CARRIAGE DENSITY IN PAPUA NEW GUINEAN INFANTS (ID 769)

Session Name
Vaccines - Impact of Vaccine programs and Serotype Replacement
Presenter
Authors

PNEUMOCOCCAL CARRIAGE IN CHILDREN WITH PNEUMONIA IN THREE ASIAN COUNTRIES FOLLOWING VACCINE INTRODUCTION (ID 1082)

Session Name
Vaccines - Impact of Vaccine programs and Serotype Replacement
Presenter
Authors

A DYNAMIC MODEL TO DETERMINE FACTORS REQUIRED FOR ELIMINATION OF VACCINE-TYPE CARRIAGE FOLLOWING PNEUMOCOCCAL CONJUGATE VACCINE INTRODUCTION IN THE ASIA-PACIFIC (ID 850)

Session Name
Population Sciences - Epidemiology, Economics, and Mathematical Modelling
Presenter
Authors