Jason M. M. Mwenda, Congo

World Health Organization Immunization

Author Of 3 Presentations

 Conference Calendar

DECLINING TRENDS IN MENINGITIS AMONG CHILDREN LESS THAN FIVE YEARS OF AGE FOLLOWING THE INTRODUCTION OF THE PNEUMOCOCCAL CONJUGATE VACCINES IN WEST AND CENTRAL AFRICA (ID 973)

Session Name
Vaccines - Impact of Vaccine programs and Serotype Replacement
Presenter
Authors

Abstract

Background

By 2015, pneumococcal conjugate vaccines (PCVs) had been introduced into the infant immunization programmes of most countries in West and Central Africa. We modelled the trends in meningitis cases and deaths among children before and after PCV introduction.

Methods

A total of 36,901 children under 5 years of age with suspected meningitis were enrolled at sentinel hospitals across 10 West and Central African countries between 2010 and 2016 through the Paediatric Bacterial Meningitis (PBM) Surveillance Network . To assess disease and mortality trends before and after PCV introduction, we applied interrupted time-series models and random effects meta-analysis.

Results

Across the sub-regions, there was a decline of 35% (95% CI 2-57%, p=0.04) in annual suspected meningitis cases and 26% (95% CI 3-44%, p=0.03) in laboratory confirmed meningitis in the post vs. pre-PCV period. Likewise, there was a decreased trend in mortality among suspected meningitis cases (33% decline, 95% CI -23-52%, p=0.27) post PCV introduction. There was considerable heterogeneity among countries with the larger and more precise reduction estimates in countries with >2 years post-PCV surveillance.

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Conclusions

We observed significant declines in suspected and confirmed pediatric meningitis across the sub-regions following PCV implementation. Continued monitoring, particularly in countries with more recent PCV introduction is needed.

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ANTIBIOTIC RESISTANCE PATTERNS AND PHYLOGEOGRAPHY OF STREPTOCOCCUS PNEUMONIAE ASSOCIATED WITH PAEDIATRIC MENINGITIS IN PRE- AND POST-PCV-INTRODUCTION WEST AND CENTRAL AFRICA (ID 958)

Session Name
Vaccines - Impact of Vaccine programs and Serotype Replacement
Presenter
Authors

PAEDIATRICS MENINGITIS SURVEILLANCE IN CÔTE D’IVOIRE AND USE OF IB-VPD/PBM TO MONITOR PCV IMPACT (ID 201)

Session Name
Vaccines - Impact of Vaccine programs and Serotype Replacement
Presenter
Authors

Abstract

Background

National paediatric bacterial meningitis (PBM) surveillance began in 2002 in Côte d’Ivoire. This surveillance is under the supervision of the immunization program. The aim of this work was to describe the PBM surveillance in Côte d’Ivoire and use of IB-VPD/PBM to monitor PCV impact.

Methods

The paediatric service notifies suspected cases, collect and send the CSF samples to the laboratory. The laboratory receives and analyse CSF and do the management of data. The technical, logistical and financial support were provided by WHO, CDC and Regional Laboratory of GAMBIA MRC. The national immunization program provided feedback to central level.

Results

From January 2002 to December 2019, 7769 CSF samples were submitted to the sentinel site laboratory. Of these samples, 263(3.39%) gave a positive culture with bacterial growth. S. pneumoniae, 50.57% (133 /263) H. influenzae 30.08 (87 /263) and 5.7 % (15/263) N. meningitidies over all the years of monitoring. Pneumococcal conjugate vaccine (PCV) serotypes, 5, 18C, 19F and 6A/B were identified post-vaccine introduction.

Conclusions

This surveillance generated data used for to evidence of disease burden, and advocacy to introduce in routine immunization Pneumococcal conjugate vaccine -13 (PCV 13) in 2014.

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