Adam L. Cohen, Switzerland
WHOAuthor Of 2 Presentations
DECLINING TRENDS IN MENINGITIS AMONG CHILDREN LESS THAN FIVE YEARS OF AGE FOLLOWING THE INTRODUCTION OF THE PNEUMOCOCCAL CONJUGATE VACCINES IN WEST AND CENTRAL AFRICA (ID 973)
Abstract
Background
By 2015, pneumococcal conjugate vaccines (PCVs) had been introduced into the infant immunization programmes of most countries in West and Central Africa. We modelled the trends in meningitis cases and deaths among children before and after PCV introduction.
Methods
A total of 36,901 children under 5 years of age with suspected meningitis were enrolled at sentinel hospitals across 10 West and Central African countries between 2010 and 2016 through the Paediatric Bacterial Meningitis (PBM) Surveillance Network . To assess disease and mortality trends before and after PCV introduction, we applied interrupted time-series models and random effects meta-analysis.
Results
Across the sub-regions, there was a decline of 35% (95% CI 2-57%, p=0.04) in annual suspected meningitis cases and 26% (95% CI 3-44%, p=0.03) in laboratory confirmed meningitis in the post vs. pre-PCV period. Likewise, there was a decreased trend in mortality among suspected meningitis cases (33% decline, 95% CI -23-52%, p=0.27) post PCV introduction. There was considerable heterogeneity among countries with the larger and more precise reduction estimates in countries with >2 years post-PCV surveillance.
Conclusions
We observed significant declines in suspected and confirmed pediatric meningitis across the sub-regions following PCV implementation. Continued monitoring, particularly in countries with more recent PCV introduction is needed.
NOVEL DIAGNOSTIC TOOL DETECTS STREPTOCOCCUS PNEUMONIAE AND VIRAL COINFECTION AMONG SUSPECTED MENINGITIS CASES. (ID 1114)
- Dam Khan, Gambia
- Brenda Kwambana-Adams, United Kingdom
- Jie Liu,
- Catherine Okoi,
- Jason Mwenda,
- Nuredin I. Mohammed,
- Enyonam Tsolenyanu, Togo
- Lorna A. Renner,
- Daniel Ansong,
- Beckie N. Tagbo,
- M F. Bashir,
- Mamadou H. Korma,
- Mohamadou Sonko,
- Jean Gratz,
- Archibald Worwui,
- Peter S. Ndow,
- Adam L. Cohen, Switzerland
- Fatima SERHAN, Switzerland
- Richard Mihigo,
- Martin Antonio, Gambia
- Eric Houpt,