Eleni Vergadi (Greece)

University of Crete Department of Pediatrics

Author Of 2 Presentations

Conference Calendar

Topic 2 Lymph node associated infections: Case Discussions Introduction - Part II

Date

Mon, 09.05.2022

Session Time

13:00 - 18:25

Session Type

Walter Marget Workshop

Session Name

0070 - WALTER MARGET EDUCATIONAL WORKSHOP (ID 21)

Room

MC 2 HALL

Presenter

Eleni Vergadi (Greece)

Lecture Time

17:10 - 17:12

CHARACTERISTICS OF CHILDREN HOSPITALIZED WITH MIS-C DURING THREE PANDEMIC WAVES IN GREECE

Date

Wed, 11.05.2022

Session Time

13:40 - 15:10

Session Type

Joint Symposium

Session Name

0385 - JOINT SYMPOSIUM: PIDS-ESPID (ID 59)

Room

BANQUETING HALL

Presenter

IRINI ELEFTHERIOU (Greece)

Lecture Time

14:50 - 14:58

Abstract

Abstract

Backgrounds:

The Multisystem Inflammatory Syndrome in Children (MIS-C) is a rare but potentially severe complication of COVID-19.

Methods

This is a retrospective observational study of children aged <18 years hospitalized with MIS-C in 10 tertiary hospitals in Greece during three pandemic waves characterized by different SARS-CoV-2 variant: i. from August 2020 to January 2021 (EU1-B.1.177), ii. from February 2021 to July 2021 (Alpha-B.1.1.7) and iii. from August 2021 to December 2021 (Delta-B.1.617.2). The aim of the study was to document the incidence over time, clinical characteristics and outcome of children admitted with MIS-C in Greek hospitals during the COVID-19 pandemic.

Results:

table 1.jpg

In total, 119 patients were included, 91.6% (109/119) met the WHO criteria of MIS-C diagnosis: 26.9% (32/119), 39.5% (47/119) and 33.6% (40/119) were hospitalized during the 1st, 2nd, and 3rd study period, respectively. Demographic and clinical characteristics are shown in Table 1. No cases were found before October 2020. The incidence of MIS-C significantly decreased over the three waves from 3.3/1000 to 0.25/1000 confirmed COVID-19 cases (P <0.0001). No other significant difference was observed in the clinical manifestations and disease severity of children hospitalized with MIS-C over the three waves.

Conclusions/Learning Points:

This study indicates that the incidence of MIS-C may vary according to the predominant variant. Outcome remains favourable regardless of the variant leading to MIS-C. Larger studies are needed to clarify if clinical characteristics and/or disease severity may differ, as well.

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