Welcome to the 13th International Congress on Autoimmunity interactive program
WHAT’S NEW IN LUPUS NEPHRITIS THERAPY? (ID 902)
IS039 - RA AND THE BRAIN (ID 903)
Abstract
Abstract Body
Rheumatoid arthritis (RA) was initially described as an inflammatory and destructive disease of synovial joints. However, over the last 20 years increasing focus has been directed towards the effects of chronic systemic inflammation on other organ systems. It is now clear that inflammation plays an important negative role in the development of cardiovascular disease and that DMARDs can reduce this risk. More recent research has considered the increased risk of brain related pathology such as stroke along with pain, depression/anxiety and even cognitive function. It has also been suggested that RA provides a model system to explore the consequences of chronic inflammation of relevance to all populations. This may be true for cardiovascular disease and dementia.
THE REPERTOIRE OF AUTOANTIBODIES IN CELIAC DISEASE: ANY NEW ONE? (ID 905)
IS040 - THE AUTOIMMUNE TAUTOLOGY: AN UP-DATE (ID 906)
Abstract
Abstract Body
Autoimmune diseases (ADs) exhibit a wide range of phenotypes depending on the target organ, however, their physiopathological mechanisms are similar. The holistic approach to ADs is known as the autoimmune tautology hypothesis, which is supported by ten arguments. First, the female predominance. Second, shared subphenotypes. Third, polyautoimmunity. Fourth, coaggregation (familial autoimmunity). Fifth, the influence of age at onset on severity. Sixth, similar pathophysiology. Seventh, similar environmental agents influence their development (that is, autoimmune ecology). Eighth, common genetic polymorphism are associated factors. Ninth, ancestry plays an importnat role, mainly in admixed populations. Lastly, Similar medications are used to treat ADs. In this lecture, I will discuss the most recent evidence that supports the autoimmune tautology.