Abstract Body

Autoimmune diseases (ADs) exhibit a wide range of phenotypes depending on the target organ, however, their physiopathological mechanisms are similar. The holistic approach to ADs is known as the autoimmune tautology hypothesis, which is supported by ten arguments. First, the female predominance. Second, shared subphenotypes. Third, polyautoimmunity. Fourth, coaggregation (familial autoimmunity). Fifth, the influence of age at onset on severity. Sixth, similar pathophysiology. Seventh, similar environmental agents influence their development (that is, autoimmune ecology). Eighth, common genetic polymorphism are associated factors. Ninth, ancestry plays an importnat role, mainly in admixed populations. Lastly, Similar medications are used to treat ADs. In this lecture, I will discuss the most recent evidence that supports the autoimmune tautology.