005 - SEROTYPE DISTRIBUTION AND VACCINE COVERAGE RATES AMONG STREPTOCOCCUS PNEUMONIAE ISOLATES CAUSING INVASIVE PNEUMOCOCCAL DISEASE IN CHILDREN IN TURKEY (ID 884)

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Abstract

Background

Streptococcus pneumoniae infections are challenging due to pneumococci having more than 90 serotypes. Vaccination is the only available tool to prevent pneumococcal disease. This ongoing study is aimed to evaluate serotype distribution and vaccine coverage rates among S. pneumoniae causing invasive pneumococcal disease in children (<18 y).

Methods

S. pneumoniae strains were isolated from 24 different centers in Turkey, located in all geographical regions between November 2018 and March 2022. Serotyping was performed using conventional methods.

Results

Eighty -one invasive isolates have been collected from children <18 years of age to date (62% of males). Fifty-seven % were < 5 y and 43% were between 6 and 18 y. The isolates were mostly collected from blood Eighty (62 %) and cerebrospinal fluid (21%). Most common serotypes were 3 (18,5%),15A (6%) and 14 (6%) in <18 y age group. The conjugate vaccine coverage rates are summarized in Table 1.

Table-1. Vaccine coverage rates

Total, N=81
n (%)

7-valent

14(17)

10-valent

14 (17)

13-valent

34(41,9)

15-valent

34 (41,9)

20-valent

44(54.3)

Conclusions

It has been observed in time that while vaccine serotypes are decreasing, serotypes not covered by vaccines are increasing. Accordingly, surveillance is essential to determine vaccination policy.

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