006 - ESTIMATION OF SUSPECTED MENINGITIS BURDEN IN CHILDREN UNDER 5 YEARS OLD IN 14 NORTHERN PROVINCES OF VIETNAM (ID 431)

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Abstract

Background

Pneumococcal conjugate vaccines (PCV) have been shown to significantly reduce the burden of vaccine-preventable meningitis. Vietnam has not yet introduced PCV into its routine immunization program. We aimed to estimate the burden of suspected meningitis cases admitted to large pediatric hospitals in Hanoi.

Methods

We retrospectively reviewed hospital records among children aged <5 years discharged from large (>200 beds) provincial-level pediatric hospitals in 14 Northern Region provinces to identify suspected meningitis cases. Data were collected from patients admitted January 1, 2017 through December 31, 2018. Suspected meningitis cases were identified using a pre-defined list of ICD-10 discharge diagnosis codes. Census data was used for the catchment population, which was children aged <5 years living in 14 Northern provinces.

Results

During the study period, 1,434 suspected meningitis cases were identified in 14 provinces of the Northern Region, including 582 cases in 2017 and 852 in 2018; National Pediatric Hospital (NPH) in Hanoi accounted for 691 (48%) of these cases. Among patients with suspected meningitis, 718 (55%) were aged ≤12 months and 596 (45%) were 13-59 months; 884 (62%) were male. The most common ICD-10 codes identified in this assessment corresponded to unspecified viral encephalitis, enteroviral meningitis and bacterial meningitis. The annual incidence of suspected meningitis cases among children was 24.6 per 100,000.

Conclusions

Meningitis remains a significant burden in children <5 years in northern Vietnam, including meningitis caused by vaccine-preventable bacterial pathogens. This data will provide a useful baseline to assess impact from pediatric PCV introduction, which is anticipated in the next few years.

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