014 - MORTALITY ASSOCIATED WITH INVASIVE PNEUMOCOCCAL DISEASE IN A COLOMBIAN PEDIATRIC POPULATION (2008-2019). (ID 592)
- Jaime A. Patiño Niño (Colombia)
- German Camacho Moreno (Colombia)
- Aura L. Leal Castro (Colombia)
- Vivian Marcela Moreno Mejia (Colombia)
- Ivan Felipe Gutierrez Tobar (Colombia)
- Sandra J Beltran Higuera (Colombia)
- Cristina Mariño Drews (Colombia)
- Martha Isabel Alvarez-Olmos (Colombia)
- Rocio Barrero Barreto (Colombia)
- Juan Pablo Rojas (Colombia)
- Fabio Espinosa (Colombia)
- Catalina Arango (Colombia)
- María Alejandra Suarez (Colombia)
- Monica Trujillo (Colombia)
- Eduardo López Medina (Colombia)
- Pio Lopez (Colombia)
- Wilfrido Coronell (Colombia)
- Nicolas Ramos (Colombia)
- Hernando Pinzón (Colombia)
- Alejandro Restrepo (Colombia)
- Anita Montañez (Colombia)
Abstract
Background
Invasive Pneumococcal Disease(IPD) causes high mortality in children under 5 years. Colombia started administering PCV10 in 2012. Neumocolombia network monitors IPD in pediatric patients throughout the country since 2012.
Methods
Case series study in deceased pediatric patients with IPD admitted to 10 hospitals of Bogotá in 2008-2021, and 4 hospitals of Cali, 2 of Medellín and 1 of Cartagena in 2017-2021(preliminary data).
Results
739 cases of IPD, 85(11,5%) died. The average age of sample was 32 months (0-180 months); 65(76%) were younger than 48 months. The average hospital stay was 9 days; 75(88.2%) were admitted to the ICU. 46 cases (54%) presented pneumonia, 17(20%) bacteremia, 17(20%) meningitis and 5(5.8%) pneumonia plus meningitis. Case fatality rate was 9.7%(46/473) for pneumonia, 22.3%(17/76) for meningitis, 11.1%(17/153) for bacteremia, and 45.4%(5/11) for meningitis plus pneumonia. 51 isolates(60%) were serotyped, and the ones with the highest case fatality rate were serotype serotype 19A with 11.8%(15/127); 3 with 10.8%(5/46) and serotype 14 with 10.7%(7/65). 21 cases (24.7%) had decreased susceptibility to penicillin.
Conclusions
Mortality from IPD is higher in children under two years. The highest lethality was found in patients with meningitis plus pneumonia, and the most lethal serotype was 19A. Permanent monitoring of mortality by IPD after the implementation of mass vaccination with PCV10 is necessary.
