009 - A 30 MONTHS RETROSPECTIVE STUDY OF ISOLATED MICRO-ORGANISMS FROM BLOOD CULTURES AND ITS SENSITIVITY PATTERN IN ADMITTED PEDIATRIC PATIENTS AT A TERTIARY PEDIATRIC HOSPITAL, KABUL, AFGHANISTAN (ID 78)
Abstract
Background
To determine the common micro-organisms responsible for blood stream infections (BSIs) in admitted pediatric patients at French Medical Institute for Mothers and Children (FMIC) in a tertiary pediatric hospital in Kabul, Afghanistan.
Methods
Retrospective study of admitted pediatric patients with positive blood cultures (BC) from 06/2018 to 06/2020 at FMIC.
Results
We analyzed 369 positive blood culture cases and the results were as indicated in the attached tables. Most of the patients (69, 8%) were patients who had a history of admission to other hospitals before being admitted to the FMIC. The majority of the isolates were multidrug resistant. Death due to gram negative pathogens was higher than gram positive pathogens. The most common organisms responsible for BSI were Staphylococcus species (including Staphyloccocus.aureus), Pseudomonas species, Klebsilla, Burkholderia Cepacia, Serratia Oderofera, and E.coli respectivily. The effective antibiotics for Gram positive pathogens were Vancomycin, Clindamycin, Amikacin and Rifampicin. The effective antibiotics for gram negative pathogens were Imipenem, Piperacillin + Tazobactum, Ceftazidime and Amikacin. The effective antifungal antibiotics in this study were Amphotericin-B and Fluconazole.
Conclusions
We observed a marked variation in pathogen distribution and resistance profiles between our institution and other Asian and African countries. Most of the pathogens from blood cultures were hospital acquired pathogens. Susceptibility results a showed resistance to commonly used antibiotics like ampicillin, Co-amoxiclov, third generation of cephalosporin, Co-trimoxazole and gentamicin. Improvement in infection prevention measures and rational use of antibiotics are crucial to decrease the incidence of infections and antibiotic resistance.
