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Sessions with voting - 
How to Investigate Normal Tissue Damages After Irradiation?
Abstract
Abstract Body
Normal tissue models have been extremely important in the discovery and development of FLASH radiotherapy. For the proper understanding of the FLASH effect, it is of the utmost importance to understand the mechanisms that result in the sparing of normal tissue. For this, it is extremely important to use proper models and methodology and use them in the correct way. Only then, we can dissect the mechanisms of the FLASH effect and proceed to a better clinical application.
In this presentation, normal tissue rat, mouse, and organoid models will be discussed, their pro’s on cons, and how to investigate therapeutic ratio addressing questions related to FLASH irradiation, such as oxygen effect, fractionation effect, dose rate effects, and local and systemic effects.
Knowledge of normal tissue models and how to use them in the context of FLASH irradiation will improve translation to the clinic.