Author Of 2 Presentations
PERIPHERAL FRACTIONAL TISSUE OXYGEN EXTRACTION IN PRETERM NEONATES WITH INFECTION/INFLAMMATION
Abstract
Background
Disturbances of peripheral (micro-)circulation and oxygenation may be the first clinical signs of infection/inflammation especially in neonates.
Objectives
The aim of the present study was to analyse peripheral muscle fractional tissue oxygen extraction (pFTOE) to investigate any changes in neonates with inflammation/infection.
Methods
In this observational study secondary outcome parameters of prospective studies were analysed. Preterm neonates <37 weeks of gestation were included, in whom peripheral muscle oxygenation was measured by near infrared spectroscopy (NIRS: NIRO 200 Hamamatsu, Japan) during 24 hours starting within 6 hours after birth. Neonates with laboratory signs of infection/inflammation on the first or second day after birth (CRP>10 and/or leucocytes>34.000/µl and/or positive blood culture) were matched for birthweight and gestational age to neonates without signs of infection/inflammation (matching ratio: 1:3). For analyses mean values of pFTOE of 3-hours-intervals was calculated and compared between the two groups.
Results
10 preterm neonates with infection/inflammation (gestational age: 32.3±2.2 weeks) were matched and compared to 30 preterm neonates without infection/inflammation (gestational age: 32.3±1.9 weeks). pFTOE was significantly higher in preterm neonates with infection/inflammation at each 3-hour-interval during the 24 hours measurement period compared to preterm neonates without infection/inflammation.
Conclusion
pFTOE is elevated during the first day after birth in preterm neonates. pFTOE measured during the first day after birth might become a new tool that helps in the early diagnosis of infection/inflammation in preterm neonates.
Video on Demand
CEREBRAL BLOOD VOLUME AND OXYGEN SATURATION DURING POSTNATAL STABILIZATION IN THE DELIVERY ROOM
Abstract
Background
In healthy newborn infants, cerebral blood volume (CBV) physiologically decreases immediately after birth. In neonates receiving respiratory support (RS) the change of cerebral blood volume (ΔCBV) is significantly smaller, most probably due to less oxygen delivery to the brain.
Objectives
The aim of this study was to investigate whether preterm neonates receiving RS and having SpO2 values below 80% 5 minutes after birth show differences in ΔCBV, compared to neonates reaching the SpO2 target of 80% or above.
Methods
We retrospectively analysed data from five prospective observational studies, including preterm neonates receiving RS during delivery room stabilization. ΔCBV was measured with near-infrared spectroscopy during the first 15 minutes after birth using the NIRO 200-NX device (Hamamatsu, Japan). Depending on the SpO2, neonates were divided into two groups: those with a 5-minute SpO2 ≥80% (≥80% group) and those with a 5-minute SpO2 <80% (<80% group).
Results
Fifty-two preterm neonates were included, 25 of whom (48.1%) were allocated to the “≥80% group” and 27 (51.9%) to the “<80% group”. There was a decrease in CBV in the “≥80% group”, whereas CBV remained unchanged in the “<80% group”. We found significant group differences for ΔCBV at minutes 3 and 4, compared to the reference values at minute 15 after birth.
Conclusion
Preterm neonates who received RS during delivery room stabilization reaching the SpO2 target of 80% at 5 minutes after birth showed a decrease in CBV. In contrast, CBV remained unchanged in the “<80% group”, which seems to be a pathological finding.
Presenter of 1 Presentation
CEREBRAL BLOOD VOLUME AND OXYGEN SATURATION DURING POSTNATAL STABILIZATION IN THE DELIVERY ROOM
Abstract
Background
In healthy newborn infants, cerebral blood volume (CBV) physiologically decreases immediately after birth. In neonates receiving respiratory support (RS) the change of cerebral blood volume (ΔCBV) is significantly smaller, most probably due to less oxygen delivery to the brain.
Objectives
The aim of this study was to investigate whether preterm neonates receiving RS and having SpO2 values below 80% 5 minutes after birth show differences in ΔCBV, compared to neonates reaching the SpO2 target of 80% or above.
Methods
We retrospectively analysed data from five prospective observational studies, including preterm neonates receiving RS during delivery room stabilization. ΔCBV was measured with near-infrared spectroscopy during the first 15 minutes after birth using the NIRO 200-NX device (Hamamatsu, Japan). Depending on the SpO2, neonates were divided into two groups: those with a 5-minute SpO2 ≥80% (≥80% group) and those with a 5-minute SpO2 <80% (<80% group).
Results
Fifty-two preterm neonates were included, 25 of whom (48.1%) were allocated to the “≥80% group” and 27 (51.9%) to the “<80% group”. There was a decrease in CBV in the “≥80% group”, whereas CBV remained unchanged in the “<80% group”. We found significant group differences for ΔCBV at minutes 3 and 4, compared to the reference values at minute 15 after birth.
Conclusion
Preterm neonates who received RS during delivery room stabilization reaching the SpO2 target of 80% at 5 minutes after birth showed a decrease in CBV. In contrast, CBV remained unchanged in the “<80% group”, which seems to be a pathological finding.
Facilitator Of
SECTION 1: ECMO CIRCUIT
SECTION 2: TROUBLESHOOTING ON ECMO
SECTION 3: ECMO CANNULATION
SECTION 4: SIMULATION SCENARIO-TEAM WORK