Session Webcast
TOXINS IN SEPTIC SHOCK
Video on Demand
BEYOND PELOD - ORGAN DYSFUNCTION ASSESSMENT IN THE NEXT DECADE
THE VOICE OF THE CONSUMER: EXPERIENCES OF FAMILIES AFFECTED BY PAEDIATRIC SEPSIS AND PRIORITIES FOR FUTURE INTERVENTION
Abstract
Background
Low public awareness of sepsis leads to delayed recognition and treatment, and increases risk of death or disability. At present, there is no integrated approach to care and follow-up family members affected by sepsis. There is a lack of studies assessing the patient and family perspective in paediatric sepsis.
Objectives
To conduct a qualitative analysis of families affected by paediatric sepsis exploring their overall experience, understanding of sepsis prior and post diagnosis, support needs during and after the acute illness, and perceived gaps in service.
Methods
Qualitative research using focus group and individual interviews to explore the experiences of a total of 10 families whose child had sepsis, at the Queensland Children’s Hospital, Brisbane, Australia. We used purposive sampling to capture a range of urban, rural and remote families impacted by sepsis. Thematic analysis was used to identify and prioritize themes to guide outcomes.
Results
Primary themes identified focus on: 1. Education of general public and healthcare sectors on childhood sepsis to improve early detection, 2. minimising isolation experienced by affected families; 3. including family members throughout treatment, education and sepsis resource development; 4. need for targeted support for families throughout the entirety of their child’s health journey including survival and bereavement.
Conclusion
Consumer-focussed research identified priorities for practice, health care organizations, and research in paediatric sepsis. In addition to public and healthcare sector education and awareness campaigns, the need for targeted support for families affected by paediatric sepsis, during and post hospitalisation was identified as a priority.
EMERGING SEROTYPE III SEQUENCE TYPE 17 GROUP B STREPTOCOCCUS INVASIVE INFECTION IN YOUNG INFANTS IN TAIWAN: THE CLINICAL CHARACTERISTICS AND IMPACTS ON OUTCOMES
Abstract
Background
Group B Streptococcus (GBS) is an important pathogen that causes a high mortality and morbidity rate in young infants. However, data of clinical manifestations between different GBS serotypes and correlation with molecular epidemiology are largely incomplete.
Objectives
To determine the serotype distribution, antimicrobial resistance, clinical features and molecular characteristics of invasive GBS isolates recovered from Taiwanese neonates.
Methods
182 non-duplicate GBS isolates that caused invasive diseases in neonates young than one year of age underwent serotyping, amltilocus sequence typing (MLST) and antibiotic susceptibility testing
Results
Of 182 invasive GBS diseases, 41 (22.5%) were early-onset disease, 121 (66.5%) were late-onset disease and 20 (11.0%) were late late-onset disease (> 90 days of age). 51 (28.0%) had meningitis, 29 (16.0%) had neurological complications after invasive GBS diseases, 12 (6.6%) died during hospitalization, and 15 (8.8%) out of 170 survival patients had long-term neurological sequelae at discharge. Serotype III GBS strains accounted for 64.8%, followed by serotype Ia (18.1%) and Ib (8.2%). MLST analysis revealed the presence of eleven different sequence types among the 182 isolates and ST-17 was the most dominant sequence type (56.6%). A correlation between serotype III and ST17 was evident, as ST17 accounted for 87.3% of all serotype III isolates. There was an obvious increasing trend of type III/ST-17 GBS that caused invasive disease in neonates. All isolates were susceptible to penicillin, cefotaxime, and vancomycin, while 68.1% and 65.9% were resistant to erythromycin and clindamycin, respectively.
Conclusion
Invasive GBS disease still can cause adverse outcomes and development of serotype-based vaccine will be necessary.
Presentation files
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ESPNIC 2019, Salzburg, Austria, Final 19.06.2019 10:00
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ESPNIC 2019, Salzburg, Austria, final 3 19.06.2019 10:47
Video on Demand
PERIPHERAL FRACTIONAL TISSUE OXYGEN EXTRACTION IN PRETERM NEONATES WITH INFECTION/INFLAMMATION
Abstract
Background
Disturbances of peripheral (micro-)circulation and oxygenation may be the first clinical signs of infection/inflammation especially in neonates.
Objectives
The aim of the present study was to analyse peripheral muscle fractional tissue oxygen extraction (pFTOE) to investigate any changes in neonates with inflammation/infection.
Methods
In this observational study secondary outcome parameters of prospective studies were analysed. Preterm neonates <37 weeks of gestation were included, in whom peripheral muscle oxygenation was measured by near infrared spectroscopy (NIRS: NIRO 200 Hamamatsu, Japan) during 24 hours starting within 6 hours after birth. Neonates with laboratory signs of infection/inflammation on the first or second day after birth (CRP>10 and/or leucocytes>34.000/µl and/or positive blood culture) were matched for birthweight and gestational age to neonates without signs of infection/inflammation (matching ratio: 1:3). For analyses mean values of pFTOE of 3-hours-intervals was calculated and compared between the two groups.
Results
10 preterm neonates with infection/inflammation (gestational age: 32.3±2.2 weeks) were matched and compared to 30 preterm neonates without infection/inflammation (gestational age: 32.3±1.9 weeks). pFTOE was significantly higher in preterm neonates with infection/inflammation at each 3-hour-interval during the 24 hours measurement period compared to preterm neonates without infection/inflammation.
Conclusion
pFTOE is elevated during the first day after birth in preterm neonates. pFTOE measured during the first day after birth might become a new tool that helps in the early diagnosis of infection/inflammation in preterm neonates.