Following PICU and NICU training in Switzerland, Luregn Schlapbach has been working as a consultant intensivist in Australia and is currently Senior Staff Specialist at the 36-bed PICU at Lady Cilento Children`s Hospital in Brisbane, Australia. He is leading the Sepsis, Infection and Inflammation research at the Paediatric Critical Care Research Group, Mater Research Institute, University of Queensland. He is ANZICS representative on the Paediatric Surviving Sepsis Campaign and Chair of the Statewide Paediatric Sepsis Group. Dr Schlapbach`s research has focused on inflammation and infections in critically ill neonates and children, including aspects such as epidemiology, immunology and sepsis markers, outcomes and genomics in this highly vulnerable patient group. He is interested in improving our understanding of why some children become critically unwell because of infections, and in developing better approaches to allow early recognition and targeted treatment of severe infections in children. He has been leading the Swiss Pediatric Sepsis Study, a prospective multicenter cohort investigating epidemiology and genomics of blood culture proven sepsis in neonates and children. Collaborations include the FP7 EUCLIDS and H2020 PERFORM consortia led by Imperial College London. A/Prof Schlapbach is investigator on several NHMRC grants and is responsible for a large multinational RCT in infants requiring cardiopulmonary bypass.

Author Of 4 Presentations

BEYOND PELOD - ORGAN DYSFUNCTION ASSESSMENT IN THE NEXT DECADE

Room
Mozart Hall 1
Date
19.06.2019
Session Time
09:10 - 10:40
Session Name
Duration
20 Minutes

Presentation files

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THE VOICE OF THE CONSUMER: EXPERIENCES OF FAMILIES AFFECTED BY PAEDIATRIC SEPSIS AND PRIORITIES FOR FUTURE INTERVENTION

Room
Mozart Hall 1
Date
19.06.2019
Session Time
09:10 - 10:40
Session Name
Duration
10 Minutes

Abstract

Background

Low public awareness of sepsis leads to delayed recognition and treatment, and increases risk of death or disability. At present, there is no integrated approach to care and follow-up family members affected by sepsis. There is a lack of studies assessing the patient and family perspective in paediatric sepsis.

Objectives

To conduct a qualitative analysis of families affected by paediatric sepsis exploring their overall experience, understanding of sepsis prior and post diagnosis, support needs during and after the acute illness, and perceived gaps in service.

Methods

Qualitative research using focus group and individual interviews to explore the experiences of a total of 10 families whose child had sepsis, at the Queensland Children’s Hospital, Brisbane, Australia. We used purposive sampling to capture a range of urban, rural and remote families impacted by sepsis. Thematic analysis was used to identify and prioritize themes to guide outcomes.

Results

Primary themes identified focus on: 1. Education of general public and healthcare sectors on childhood sepsis to improve early detection, 2. minimising isolation experienced by affected families; 3. including family members throughout treatment, education and sepsis resource development; 4. need for targeted support for families throughout the entirety of their child’s health journey including survival and bereavement.

Conclusion

Consumer-focussed research identified priorities for practice, health care organizations, and research in paediatric sepsis. In addition to public and healthcare sector education and awareness campaigns, the need for targeted support for families affected by paediatric sepsis, during and post hospitalisation was identified as a priority.

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VALIDATION OF THE PEDIATRIC SEPSIS SCORE IN A DUTCH NATIONAL COHORT OF CHILDREN ADMITTED TO PICU WITH SEPSIS

Abstract

Background

Early recognition of high-risk sepsis patients is crucial for enrolment in trials, and to select patients for targeted therapies. The pediatric sepsis score is a prediction model for sepsis mortality, using a simple set of variables available within 60mins of ICU admission (Schlapbach LJ et al. Intensive Care Med.2017 Aug;43(8):1085-1096).

Objectives

We aimed to validate this score in an independent cohort.

Methods

Retrospective multicenter cohort study based on prospectively collected data from the Dutch Pediatric Intensive Care Evaluation (PICE) registry. We included patients <16 years admitted with sepsis and/or septic shock to PICU from 2003-2016. The pediatric sepsis score was calculated using variables available at PICU admission. Lactate data was not available. The primary outcome was mortality and secondary outcome was mortality and/or PICU length of stay (LOS) ≥72h.

Results

We included 1929 admissions for sepsis and septic shock (57% male; median age 2.2y; IQR 6m-8.2y), of which 257/1929 (13.3%) died and 1162/1929 (60.2%) admissions resulted in mortality and/or PICU LOS ≥72h. Both primary and secondary outcome strongly correlated with the sepsis score (p<0.001). The pediatric sepsis score predicted mortality with an AUC of 0.698 (95%-CI 0.677-0.718) and mortality/PICU LOS ≥72h with an AUC of 0.711 (95%-CI 0.690-0.731).

Conclusion

Validation of the pediatric sepsis score in an independent dataset demonstrates that it is a robust tool to predict mortality, and mortality and/or prolonged ICU stay in children admitted to PICU with sepsis. The lack of lactate data in the validation dataset may have contributed to the lower predictive performance compared to the original study.

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Video on Demand

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BIG DATA IN THE INTENSIVE CARE UNIT: WILL IT HELP?

Room
Mozart Hall 1
Date
20.06.2019
Session Time
11:10 - 12:10
Session Name
Duration
20 Minutes

Presentation files

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Presenter of 3 Presentations

BEYOND PELOD - ORGAN DYSFUNCTION ASSESSMENT IN THE NEXT DECADE

Room
Mozart Hall 1
Date
19.06.2019
Session Time
09:10 - 10:40
Session Name
Duration
20 Minutes

Presentation files

Hide

THE VOICE OF THE CONSUMER: EXPERIENCES OF FAMILIES AFFECTED BY PAEDIATRIC SEPSIS AND PRIORITIES FOR FUTURE INTERVENTION

Room
Mozart Hall 1
Date
19.06.2019
Session Time
09:10 - 10:40
Session Name
Duration
10 Minutes

Abstract

Background

Low public awareness of sepsis leads to delayed recognition and treatment, and increases risk of death or disability. At present, there is no integrated approach to care and follow-up family members affected by sepsis. There is a lack of studies assessing the patient and family perspective in paediatric sepsis.

Objectives

To conduct a qualitative analysis of families affected by paediatric sepsis exploring their overall experience, understanding of sepsis prior and post diagnosis, support needs during and after the acute illness, and perceived gaps in service.

Methods

Qualitative research using focus group and individual interviews to explore the experiences of a total of 10 families whose child had sepsis, at the Queensland Children’s Hospital, Brisbane, Australia. We used purposive sampling to capture a range of urban, rural and remote families impacted by sepsis. Thematic analysis was used to identify and prioritize themes to guide outcomes.

Results

Primary themes identified focus on: 1. Education of general public and healthcare sectors on childhood sepsis to improve early detection, 2. minimising isolation experienced by affected families; 3. including family members throughout treatment, education and sepsis resource development; 4. need for targeted support for families throughout the entirety of their child’s health journey including survival and bereavement.

Conclusion

Consumer-focussed research identified priorities for practice, health care organizations, and research in paediatric sepsis. In addition to public and healthcare sector education and awareness campaigns, the need for targeted support for families affected by paediatric sepsis, during and post hospitalisation was identified as a priority.

Hide

Presentation files

Hide

BIG DATA IN THE INTENSIVE CARE UNIT: WILL IT HELP?

Room
Mozart Hall 1
Date
20.06.2019
Session Time
11:10 - 12:10
Session Name
Duration
20 Minutes

Presentation files

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Moderator of 4 Sessions

SHORT SCIENTIFIC SESSION
Room
Mozart Hall 1
Date
19.06.2019
Session Time
11:10 - 12:10

Session Webcast

SHORT ORAL PRESENTATION
Room
Papageno Hall
Date
19.06.2019
Session Time
13:40 - 15:10
INTERDISCIPLINARY SESSION
Room
Doppler Hall
Date
20.06.2019
Session Time
15:40 - 17:10
POSTER WALK
Room
Poster Area 2
Date
20.06.2019
Session Time
12:20 - 13:40