Nicole Ritz (Switzerland)

Children’s Hospital in Lucerne Paediatrics
Nicole Ritz, MD, PhD, Paediatrican and Infectious Diseases Specialist Short biography Dr. Ritz is a paediatrican and infectious diseases specialist. She is the head of paediatrics at the Children’s Hospital in Lucerne, Switzerland and leads the Mycobacterial and Migrant Health Research Laboratory at the Department of Clinical Research the University Children's Hospital Basel, Switzerland. She trained in Switzerland, South Africa and Australia, obtained her MD at the University of Berne and her PhD at the University of Melbourne Dr. Ritz received her habilitation in paediatrics and infectious diseases in 2015. Her current research focuses on developing novel immunodiagnostic assays for children with tuberculosis and on biomarkers for the diagnosis of respiratory tract infections. The over 15 years’ experience in leading and collaborating in research studies have resulted in over 100 publications with a focus on childhood TB, migrant health, and biomarkers for the diagnosis of infectious diseases. Dr. Ritz is an ESPID member since 2005 and has received an ESPID fellowship-award in 2006. She has trained young scientist in the ESPID research masterclass from 2015-2019 and organized the ESPID annual meeting 2021 as a co-chair hosted in Geneva. She has had the honour to pass the torch over land and sea to Maria Tsolia for ESPID 2022 in Athens.

Author Of 2 Presentations

Expert

Date
Wed, 11.05.2022
Session Time
18:30 - 19:20
Session Type
Meet The Experts
Room
BANQUETING HALL
Lecture Time
18:30 - 18:30

DIAGNOSTIC PERFORMANCE IN A MULTICENTRE STUDY USING FULL BLOOD COUNTS FOR THE NEUTROPHIL-TO-LYMPHOCYTE AND MONOCYTE-TO-LYMPHOCYTE RATIO FOR THE DIAGNOSIS OF PAEDIATRIC TUBERCULOSIS

Date
Fri, 13.05.2022
Session Time
10:00 - 11:30
Session Type
Oral Presentations Session
Room
MC 2 HALL
Lecture Time
11:12 - 11:22

Abstract

Backgrounds:

The monocyte-to-lymphocyte ratio (MLR) and neutrophil-to-lymphocyte ratio (NLR) are easy to obtain markers from full blood counts. Little is known about the diagnostic accuracy of these ratios in children evaluated for tuberculosis (TB) compared to sick controls.

Methods

Data of two prospective multicentre studies in Switzerland were used: the CITRUS study and the ProPAED study. The CITRUS study included children <18 years with TB exposure (TB-E), TB infection (TB-I) or TB disease (TB-D). The ProPAED study included children 1 month to 18 years of age with fever and lower respiratory tract infection (viral or bacterial) and these were the sick controls (SC).

Results:

A total of 379 children were included in this analysis; 19 with TB-D, 12 with TB-I, 24 TB-E and 324 SC. Median age was 3.08 (IQR [1.37, 6.06]) years and 58% were male. Median NLR was highest in TB-D (2.05 [1.41, 2.64]) and significantly higher compared to children with TB-I (1.08 [0.82, 1.55]), TB-E (0.80 [0.63, 1.33]) and SC (0.31 [0.11, 0.97]) (all p-values < 0.05). Median MLR was similar in TB-D (0.25 [0.18, 0.34]) and SC (0.34 [0.21, 0.58]), but significantly higher in TB-D and TB-I when compared to TB-E (both p-values <0.05). Receiver operating characteristic curves of the ratios were calculated for children with TB-D and SC. NLR and MLR had at cut-off 0.75 and 0.63, an area under the curve of 0.84 and 0.63, sensitivity of 0.94 and 0.94, and specificity of 0.7 and 0.3, respectively. Similar results were obtained after adjustment for age.

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Conclusions/Learning Points:

This study shows that NLR and MLR are promising easy-to-obtain diagnostic markers to differentiate children TB-D from non-TB lower respiratory tract infections. These results require confirmation in a larger study sample.

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Presenter of 1 Presentation

Expert

Date
Wed, 11.05.2022
Session Time
18:30 - 19:20
Session Type
Meet The Experts
Room
BANQUETING HALL
Lecture Time
18:30 - 18:30

Moderator of 1 Session

Session Type
Parallel Symposium
Date
Wed, 11.05.2022
Session Time
15:40 - 17:10
Room
NIKOS SKALKOTAS HALL