Ulrich Heininger (Switzerland)

University of Basel Children's Hospital Paediatric Infectious Diseases and Vaccinology

Ulrich Heininger has been in charge of the Division of Paediatric Infectious Diseases and Vaccinology at the University of Basel Children’s Hospital, Basel, Switzerland, since 1998. He is a professor of paediatrics at the University of Basel and his research is focused on vaccine-preventable diseases, vaccines, and vaccine safety. Ulrich Heininger was a cofounder of “The Brighton Collaboration” in 2000, dealing with vaccine safety issues, and served a member of the Global Advisory Committee on Vaccine Safety (GACVS) of the World Health Organization 2014-2020. He is one of 9 scientists and founding member running the INFOVAC service, a Swiss nationwide information network for vaccine related questions raised by physicians and pharmacists. Ulrich Heininger has been member of the National Immunization Technical Advisory Groups (NITAG) of Germany since 2001 and of Switzerland from 2004 to 2019, respectively. He was treasurer (1999-2005) and president (2009-2012) of the European Society of Pediatric Infectious Diseases, ESPID and serves on the editorial board of several scientific journals. He has published more than 300 scientific publications in the field of infectious diseases and vaccines.

Author Of 2 Presentations

Conference Calendar

Forgotten Wisdom – The Most Influential Studies You Need To Have Heard Of

Date

Wed, 11.05.2022

Session Time

17:15 - 18:15

Session Type

Plenary Symposium

Session Name

0445 - PLENARY SYMPOSIUM: Forgotten Wisdom (ID 67)

Room

ALEXANDRA TRIANTI HALL

Presenter

Ulrich Heininger (Switzerland)

Lecture Time

17:57 - 18:05

VALIDATION OF PEDIATRIC ORGAN DYSFUNCTION SCORES IN CHILDREN WITH BLOOD CULTURE-PROVEN INFECTION – A NATIONAL PROSPECTIVE COHORT STUDY

Date

Fri, 13.05.2022

Session Time

10:00 - 11:30

Session Type

Oral Presentations Session

Session Name

0885 - ORAL PRESENTATION SESSION 08: Public Health & Non-Respiratory Infections (ID 106)

Room

DIMITRIS MITROPOULOS HALL

Presenter

Philipp K. Agyeman (Switzerland)

Lecture Time

10:42 - 10:52

Abstract

Abstract

Backgrounds:

Previous studies applying Sepsis-3 criteria to pediatric sepsis were based on retrospective analyses of pediatric intensive care unit (PICU) cohorts. We aimed to validate organ dysfunction criteria in a population-based cohort of children with blood culture-proven infection, including emergency department, PICU, and ward patients.

Methods

National multi-center prospective cohort study of children <17 years with blood culture-proven sepsis between 1.9.2011 and 31.12.2015. We excluded preterm infants and neonates ≤7 days. We compared the 2005 International Pediatric Sepsis Consensus Conference (IPSCC), Pediatric Logistic Organ Dysfunction (PELOD)-2, pediatric Sequential Organ Failure Assessment (pSOFA), and Pediatric Organ Dysfunction Information Update Mandate (PODIUM) scores measured on day of blood culture sampling to predict 30-day mortality using area under the receiver-operating characteristic curves (AUC). Conditional random forest analyses and generalized linear mixed model prediction were used.

Results:

We analyzed 877 sepsis episodes in 807 children, with a 30-day mortality of 4.3%. Presence of any organ dysfunction ranged from 32.7% (2005 IPSCC) to 55.3% (pSOFA). In adjusted analyses, the accuracy to predict mortality was highest for 2005 IPSCC (AUC 0.871, 95%CI: 0.819−0.924), followed by pSOFA (0.852; 95%CI: 0.784−0.92), PODIUM (0.852; 95%CI: 0.791−0.912), and PELOD-2 (0.827; 95%CI: 0.761−0.892). Neurologic, respiratory, and cardiovascular dysfunction were most predictive of 30-day mortality. Considering only these three organs adjusted AUC was 0.784 (0.70 - 0.868) for 2005 IPSCC and 0.771 (0.684-0.857) for PODIUM, while pSOFA (0.734; 0.641-0.828) and PELOD-2 (0.724; 0.627-0.822) had lower performances.

Conclusions/Learning Points:

When comparing scores for organ dysfunction, 2005 IPSCC performed best, followed by pSOFA and PODIUM criteria. Although the accuracy between scores was comparable, we observed major differences in terms of classification of individual organ dysfunctions. Our findings confirm the importance of neurologic, respiratory, and cardiovascular dysfunction.

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