Monica Marino, Italy
Azienda Ospedaliero-Universitaria Ospedali Riuniti Ancona Women's and Children's HealthPresenter of 1 Presentation
ASSOCIATION OF MACRONUTRIENTS INTAKE WITH CGM-BASED TIME IN RANGE IN CHILDREN WITH T1D
- Monica Marino, Italy
- Claudio Maffeis, Italy
- Antonietta Chianese, Italy
- Marco Marigliano, Italy
- Serena Rollato, Italy
- Sara Giorda, Italy
- Davide Tinti, Italy
- Dario Iafusco, Italy
- Antonella Lorubbio, Italy
- Riccardo Schiaffini, Italy
- Letizia Tomaselli, Italy
- Antonio Iannilli, Italy
- Rosaria Gesuita, Italy
- Valentino Cherubini, Italy
Abstract
Background and Aims
To evaluate the association between clinical factors and macronutrients intake with CGM-based time in range (TIR) in children with T1D.
Methods
A multi-center cross-sectional study recruited children with T1D, aged 2-17y, HbA1c < 86 mmol/mol, using CGM, during Jan 2019-Jan 2020 in Italy. Diet intake was collected through three day weighed food diaries. Nutrients were evaluated as percentages of total intake and summarized as median and (IQR). TIR was considered at target if the percentage of readings and time 70-180 mg/dL was higher than 70%. Clinical and nutritional factors associated to TIR at target were analysed using multiple logistic regression, results were expressed as OR and 90%CI.
Results
Data were available for 197 children, 53% male, 47% using CSII, median age 11.6y (8.6-14.3), HbA1c 55 mmol/mol (48-61). Median nutrients intake was Protein, P 16.9% (14.4-19), SFA 9.6% (7.8-10.9), polyunsaturated fatty acid, PUFA 10.3% (7-14.9), monounsaturated fatty acid, MUFA 16.4% (13.8-19.4), carbohydrates, CHO 45.9% (42.3-49.1). TIR at target was observed in 28% of participants; median TIR was 60% (47-71). Increasing diabetes duration and complex CHO assumption significantly reduced the probability to reach TIR>70%. Use of CHO counting, and higher fat consumption were associated with an increase probability to achieve TIR>70%.
Conclusions
Less than 30% of the observed population reached the TIR>70%. Both clinical and nutritional factors are associated with TIR at target. This study highlights the role of CHO counting and macronutrient intake in modulating CGM-based glycemic targets in children and adolescents with T1D.