Natalia Chernikova, Russian Federation
RMACPE endocrinologyPresenter of 2 Presentations
THE FOCUS ON THE PROFESSIONAL GLUCOCARDIOMONITORING AT THE PATIENTS WITH TYPE 2 DIABETES MELLITUS
Abstract
Background and Aims
The main reason for the complications of Type 2 Diabetes Mellitus (T2DM) and T2DM-death is cardiovascular. The high glycemic variability (GV) influences on the cardiac dysfunction. The continuous glucose monitoring (CGM) becomes the available clinical component. The aim is to establish the quantitative interplay between the glycemic CGM-GV and the Holter monitoring (HM) parameters at T2DM
Methods
In the observational study 454 patients with T2DM were included. During 5 days Professional CGM using iPro2 and HM synchronically were performed. The data were treated with Statistica19.0.
Results
We determined that the Ventricular arrhythmias (VAs) were associated with high GV and hyperglycemia. The Pearson correlation coefficients (σ) between VAs and SGM-parameters were 1,0 with Time in hyperglycemia (TIR-HYPER), -0,615 - Time in normoglycemia (TIR-NORMO), 0,104 - Time in hypoglycemia (TIR-HYPO), 0,006 - Minimal glycemia level (MinGl), 0,591 - Maximal glycemia level (MaxGl), 0,467 - Average glycemia level (AvGl), 0,727 - Glycemic Fluctuations >4 mmol/L/hr (GF>4), 0,564 - Standard deviation (SD). Also σ between Depression ST and SGM-parameters were 0,102 (TIR-HYPER), -0,181 (TIR-NORMO), 0,394 (TIR-HYPO), -0,136 (MinGl), 0,098 (MaxGl), 0,062 (AvGl), 0,158 (GF>4), 0,121 (SD). The prolongation of the QTc interval is maximally correlated with TIR-HYPO (σ=0,333).
Conclusions
The glucocardiomonitoring is the valuable clinical instrument for the early detection of T2DM-patients with high GV and high cardiological risk and the further optimization of T2DM-management
PROFESSIONAL MONITORING FOR TYPE 2 DIABETES MELLITUS: CONTRIBUTION TO GLYCEMIC VARIABILITY FROM RELIGIOUS FASTING
Abstract
Background and Aims
The minimizing of the glycemic variability (GV) is the priority task at Type 2 Diabetes Mellitus (T2DM) management. The religious fasting (RF) is the period when the differences in food, drugs and schedule take place. Aim: to investigate GV using the continuous glucose monitoring (CGM) at the patients with T2DM at RF and without RF to determine the GV-CGM-characteristics associated with RF
Methods
110 patients with T2DM took part in CGM using iPro2 (5 days). We assessed the differences in the GV-CGM-parameters at RF (n=55) and without RF (n=55). The data array was treated with Statistica19.0, the distinctions were significant if p<0,05
Results
The main CGM-parameters at and without RF were the following (medians): 34 and 22% Time in hyperglycemia (TIR-HYPER), p<0,05; 66 and 76% Time in normoglycemia (TIR-NORMO), p>0,05; 0 and 2% Time in hypoglycemia, p>0,05; 4,6 and 4,2 mmol/L Minimal glycemia, p>0,05; 12,1 and 9,2 mmol/L Maximal glycemia (MaxGl), p<0,05; 8,9 and 7,9 mmol/L Average glycemia (AvGl), p<0,05; 2,4 and 1,3 Glycemic Fluctuations >4 mmol/L (GF>4), p<0,05; 2,4 and 1,4 Standard deviation (SD) mmol/L, p<0,05. The coefficient variation CV was 28,5±4,3 and 18,9±2,1%, p<0,05
Conclusions
The postprandial hyperglycemia is the main factor influenced on the GV-raising (increase MaxGl, AvGl, TIR-HYPER, SD, FG>4, CV; decrease TIR-NORMO), if the endocrinological safety rules for RF don’t carry out. Professional CGM during RF is necessary in real-life clinical practice