The main reason for the complications of Type 2 Diabetes Mellitus (T2DM) and T2DM-death is cardiovascular. The high glycemic variability (GV) influences on the cardiac dysfunction. The continuous glucose monitoring (CGM) becomes the available clinical component. The aim is to establish the quantitative interplay between the glycemic CGM-GV and the Holter monitoring (HM) parameters at T2DM
In the observational study 454 patients with T2DM were included. During 5 days Professional CGM using iPro2 and HM synchronically were performed. The data were treated with Statistica19.0.
We determined that the Ventricular arrhythmias (VAs) were associated with high GV and hyperglycemia. The Pearson correlation coefficients (σ) between VAs and SGM-parameters were 1,0 with Time in hyperglycemia (TIR-HYPER), -0,615 - Time in normoglycemia (TIR-NORMO), 0,104 - Time in hypoglycemia (TIR-HYPO), 0,006 - Minimal glycemia level (MinGl), 0,591 - Maximal glycemia level (MaxGl), 0,467 - Average glycemia level (AvGl), 0,727 - Glycemic Fluctuations >4 mmol/L/hr (GF>4), 0,564 - Standard deviation (SD). Also σ between Depression ST and SGM-parameters were 0,102 (TIR-HYPER), -0,181 (TIR-NORMO), 0,394 (TIR-HYPO), -0,136 (MinGl), 0,098 (MaxGl), 0,062 (AvGl), 0,158 (GF>4), 0,121 (SD). The prolongation of the QTc interval is maximally correlated with TIR-HYPO (σ=0,333).
The glucocardiomonitoring is the valuable clinical instrument for the early detection of T2DM-patients with high GV and high cardiological risk and the further optimization of T2DM-management