The minimizing of the glycemic variability (GV) is the priority task at Type 2 Diabetes Mellitus (T2DM) management. The religious fasting (RF) is the period when the differences in food, drugs and schedule take place. Aim: to investigate GV using the continuous glucose monitoring (CGM) at the patients with T2DM at RF and without RF to determine the GV-CGM-characteristics associated with RF
110 patients with T2DM took part in CGM using iPro2 (5 days). We assessed the differences in the GV-CGM-parameters at RF (n=55) and without RF (n=55). The data array was treated with Statistica19.0, the distinctions were significant if p<0,05
The main CGM-parameters at and without RF were the following (medians): 34 and 22% Time in hyperglycemia (TIR-HYPER), p<0,05; 66 and 76% Time in normoglycemia (TIR-NORMO), p>0,05; 0 and 2% Time in hypoglycemia, p>0,05; 4,6 and 4,2 mmol/L Minimal glycemia, p>0,05; 12,1 and 9,2 mmol/L Maximal glycemia (MaxGl), p<0,05; 8,9 and 7,9 mmol/L Average glycemia (AvGl), p<0,05; 2,4 and 1,3 Glycemic Fluctuations >4 mmol/L (GF>4), p<0,05; 2,4 and 1,4 Standard deviation (SD) mmol/L, p<0,05. The coefficient variation CV was 28,5±4,3 and 18,9±2,1%, p<0,05
The postprandial hyperglycemia is the main factor influenced on the GV-raising (increase MaxGl, AvGl, TIR-HYPER, SD, FG>4, CV; decrease TIR-NORMO), if the endocrinological safety rules for RF don’t carry out. Professional CGM during RF is necessary in real-life clinical practice