Lois E. H. Smith M.D., Ph.D. is an ophthalmologist and clinician/scientist at Boston Children’s Hospital and Professor of Ophthalmology at Harvard Medical School. Her basic research work is in retinal neovascularization, both basic mechanism and translation to treatment including diabetic retinopathy, retinopathy of prematurity, age-related macular degeneration and retinitis pigmentosa. Her early work defined oxygen-induced retinopathy where she showed VEGF is necessary for ischemia-induced proliferative retinopathy. She defined the role of growth hormone and IGF-1 in retinopathy. She has shown that omega-3 fatty acids are critical to retinopathy and that modulating the omega-3 /omega-6 ratio in retina can inhibit pathological angiogenesis. She has focused more recently on metabolic function in photoreceptors, driving neovascularization. She serves on the editorial boards at IOVS, eLife, and Journal of Clinical Investigation. She also serves on the ARVO Awards Committee, the Helen Keller Prize Committee, the Bressler Prize Committee, the Alcon Research Institute Awards Committee and is a member of the Lowy Medical Research Institute Board of Scientific Governors. She serves as a mentor in ARVO’s Leadership Development Program for Women. She has funding from the National Eye Institute, Massachusetts Lions Eye Research Fund, the European Union, the Lowy Medical Research Institute, Foundation Fighting Blindness, Research to Prevent Blindness Senior Investigator Award, and the Alcon Award.