Welcome to the AD/PD™ 2023 Interactive Program
The conference will officially run on Central European Time (CET)
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PRE CONFERENCE SYMPOSIUM
Session Time
08:00 - 15:50
Session Type
PRE CONFERENCE SYMPOSIUM
Date
Tue, 28.03.2023
Room
ONSITE - HALL G3
Session Description
This day-long, CME credit-eligible workshop will provide participants with an understanding of the common and distinct features of neurodegenerative diseases, which include not only those affecting the brain, such as Alzheimer’s disease, Parkinson’s disease, dementia with Lewy bodies, vascular dementia, frontotemporal dementia, and mixed dementia; but also the ocular diseases including age-related macular degeneration, glaucoma, diabetic retinopathy, and inherited retinal degenerative diseases. Some questions that will be addressed during this fourth pre-symposium workshop, starting from small (Section 1. Mitochondria In Health and Neurodegeneration; and Section 2. Glucose and Lipid Metabolism) and ending with a more wholistic (Section 3. System-level Energy Dysfunction and Metabolic Disorders) point of view: •Why does the nervous system (including the brain and eyes) have a unique energy demand? •How can one evaluate metabolic fitness? •How can only tiny changes in energy, metabolism and/or mitochondria lead to neurodegenerative disease?•Is there a definite ‘tipping point’ that could be prevented in humans to delay onset of disease?•What role do comorbidities, like diabetes and other insulin/energy/metabolism-dysfunction diseases, play in neurodegenerative diseases?•How can one study this in living humans? •Are there common elements across these diseases that could give a clue to preventions and future treatments?Section 1 Summary: Mitochondria are essential organelles that regulate multiple processes essential for neuronal function including metabolic balance, intracellular calcium homeostasis, production of reactive oxygen species, and apoptotic signaling. Accumulating evidence indicates that mitochondrial defects play a central role in the pathogenesis of neurodegenerative diseases. This session will cover new insights into mitochondrial dynamics, trafficking, transmitophagy, and damage as well as novel therapeutic strategies to increase mitochondrial health in eye and brain diseases.Section 2 Summary: Individual cell-types in the brain have unique energy requirements and unique roles in meeting the energetic demands placed on the brain. Disruption in cellular cross-talk and cell-autonomous energy occur during the setting of neurodegenerative disease. A more refined disruption of the cellular and intercellular metabolic defects will likely offer new insights into neurodegenerative disease and perhaps illuminate novel therapeutic approaches.Section 3 Summary: Metabolic conditions and diabetes are risk factors for both Alzheimer’s disease and eye diseases. In addition to hypoperfusion restricting blood flow, they also impact brain energy metabolism including insulin signaling and glucose utilization. In this section, the speakers will discuss how brain metabolism and insulin signaling are impaired in these neurodegenerative conditions and how these pathways can be targeted for therapy to treat brain and eye diseases, and to promote healthy brain aging.
Supported with an educational grant by BrightFocus
WELCOME AND INTRODUCTION INCLUDING WORKSHOP GENERAL DISCUSSION PRIMER
Session Type
PRE CONFERENCE SYMPOSIUM
Date
Tue, 28.03.2023
Session Time
08:00 - 15:50
Room
ONSITE - HALL G3
Presenter
Lecture Time
08:00 - 08:15
SECTION 1: MITOCHONDRIA IN HEALTH AND NEURODEGENERATION MODERATED BY Adriana Di Polo
Session Type
PRE CONFERENCE SYMPOSIUM
Date
Tue, 28.03.2023
Session Time
08:00 - 15:50
Room
ONSITE - HALL G3
Lecture Time
08:15 - 08:15
MITOCHONDRIA AS MICROLENSES: IMPLICATIONS FOR CONE PHOTORECEPTOR FUNCTION IN HEALTH AND DISEASE
Session Type
PRE CONFERENCE SYMPOSIUM
Date
Tue, 28.03.2023
Session Time
08:00 - 15:50
Room
ONSITE - HALL G3
Presenter
Lecture Time
08:15 - 08:35
THE ROLE OF TRANSMITOPHAGY IN NEURODEGENERATIVE DISEASES
Session Type
PRE CONFERENCE SYMPOSIUM
Date
Tue, 28.03.2023
Session Time
08:00 - 15:50
Room
ONSITE - HALL G3
Lecture Time
08:35 - 08:55
PRE-RECORDED: DECODING MITOCHONDRIA DYSFUNCTION IN PARKINSON’S DISEASE
Session Type
PRE CONFERENCE SYMPOSIUM
Date
Tue, 28.03.2023
Session Time
08:00 - 15:50
Room
ONSITE - HALL G3
Lecture Time
08:55 - 09:15
MITOCHONDRIA AND TAU IN FTD
Session Type
PRE CONFERENCE SYMPOSIUM
Date
Tue, 28.03.2023
Session Time
08:00 - 15:50
Room
ONSITE - HALL G3
Presenter
Lecture Time
09:15 - 09:35
ADAPTOR PROTEIN SUPPLEMENTATION TO RESTORE MITOCHONDRIAL TRANSPORT IN GLAUCOMA
Session Type
PRE CONFERENCE SYMPOSIUM
Date
Tue, 28.03.2023
Session Time
08:00 - 15:50
Room
ONSITE - HALL G3
Presenter
Lecture Time
09:35 - 09:55
GENERAL DISCUSSION
Session Type
PRE CONFERENCE SYMPOSIUM
Date
Tue, 28.03.2023
Session Time
08:00 - 15:50
Room
ONSITE - HALL G3
Presenter
Lecture Time
09:55 - 10:25
BREAK
Session Type
PRE CONFERENCE SYMPOSIUM
Date
Tue, 28.03.2023
Session Time
08:00 - 15:50
Room
ONSITE - HALL G3
Lecture Time
10:25 - 10:40
SECTION 2: GLUCOSE AND LIPID METABOLISM MODERATED BY Todd Golde
Session Type
PRE CONFERENCE SYMPOSIUM
Date
Tue, 28.03.2023
Session Time
08:00 - 15:50
Room
ONSITE - HALL G3
Lecture Time
10:40 - 10:40
HISTORY AND USE OF FDG PET IN ALZHEIMER’S DISEASE
Session Type
PRE CONFERENCE SYMPOSIUM
Date
Tue, 28.03.2023
Session Time
08:00 - 15:50
Room
ONSITE - HALL G3
Presenter
Lecture Time
10:40 - 11:00
APOE EFFECTS ON GLIAL METABOLISM: IMPLICATIONS FOR ALZHEIMER’S DISEASE
Session Type
PRE CONFERENCE SYMPOSIUM
Date
Tue, 28.03.2023
Session Time
08:00 - 15:50
Room
ONSITE - HALL G3
Presenter
Lecture Time
11:00 - 11:20
NUTRITIONAL METABOLISM AND CEREBRAL BIOENERGETICS IN ALZHEIMER’S DISEASE AND RELATED DEMENTIAS
Session Type
PRE CONFERENCE SYMPOSIUM
Date
Tue, 28.03.2023
Session Time
08:00 - 15:50
Room
ONSITE - HALL G3
Lecture Time
11:20 - 11:40
LIPID METABOLISM IN NEOVASCULAR DISEASES OF THE EYE
Session Type
PRE CONFERENCE SYMPOSIUM
Date
Tue, 28.03.2023
Session Time
08:00 - 15:50
Room
ONSITE - HALL G3
Presenter
Lecture Time
11:40 - 12:00
GENERAL DISCUSSION
Session Type
PRE CONFERENCE SYMPOSIUM
Date
Tue, 28.03.2023
Session Time
08:00 - 15:50
Room
ONSITE - HALL G3
Presenter
Lecture Time
12:00 - 12:30
LUNCH
Session Type
PRE CONFERENCE SYMPOSIUM
Date
Tue, 28.03.2023
Session Time
08:00 - 15:50
Room
ONSITE - HALL G3
Lecture Time
12:30 - 13:30
SECTION 3: SYSTEM-LEVEL ENERGY DYSFUNCTION AND METABOLIC DISORDERS BY Guojun Bu
Session Type
PRE CONFERENCE SYMPOSIUM
Date
Tue, 28.03.2023
Session Time
08:00 - 15:50
Room
ONSITE - HALL G3
Lecture Time
13:30 - 13:30
PRE-RECORDED:METFORMIN AND AGE-RELATED MACULAR DEGENERATION
Session Type
PRE CONFERENCE SYMPOSIUM
Date
Tue, 28.03.2023
Session Time
08:00 - 15:50
Room
ONSITE - HALL G3
Lecture Time
13:30 - 13:50
DIABETES-MEDIATED COGNITIVE DECLINE; LESSONS FROM TYPE 1 AND TYPE 2 DIABETES
Session Type
PRE CONFERENCE SYMPOSIUM
Date
Tue, 28.03.2023
Session Time
08:00 - 15:50
Room
ONSITE - HALL G3
Lecture Time
13:50 - 14:10
INTERACTION BETWEEN APOE GENOTYPE AND DIABETES IN LONGEVITY AND DEMENTIA
Session Type
PRE CONFERENCE SYMPOSIUM
Date
Tue, 28.03.2023
Session Time
08:00 - 15:50
Room
ONSITE - HALL G3
Presenter
Lecture Time
14:10 - 14:30
CLINICAL TRIALS AND NAD SUPPLEMENTATION FOR GLAUCOMA
Session Type
PRE CONFERENCE SYMPOSIUM
Date
Tue, 28.03.2023
Session Time
08:00 - 15:50
Room
ONSITE - HALL G3
Presenter
Lecture Time
14:30 - 14:50
GENERAL DISCUSSION
Session Type
PRE CONFERENCE SYMPOSIUM
Date
Tue, 28.03.2023
Session Time
08:00 - 15:50
Room
ONSITE - HALL G3
Presenter
Lecture Time
14:50 - 15:20
CLOSING REMARKS
Session Type
PRE CONFERENCE SYMPOSIUM
Date
Tue, 28.03.2023
Session Time
08:00 - 15:50
Room
ONSITE - HALL G3
Presenter
Lecture Time
15:20 - 15:50