Oskar Hansson, Sweden

Lund University Clinical Sciences Malmö
Dr. Oskar Hansson gained his PhD in neurobiology in 2001 and his M.D. in 2005. He became senior consultant in neurology in 2012 at Skåne University Hospital, Sweden, and full professor of neurology in 2017 at Lund University, Sweden. Oskar Hansson has performed internationally recognized clinical and translational research focusing on the earliest phases of Alzheimer's and Parkinson’s diseases. His landmark study on cerebrospinal fluid biomarkers for Alzheimer’s disease from 2006 (Hansson et al, The Lancet Neurology, 2006) has been instrumental for the implementation of these biomarkers in the clinical work-up of Alzheimer's disease in Sweden and internationally. His work on biomarkers has led to over 300 original peer-reviewed publications. Ten years ago, he started the prospective and longitudinal Swedish BioFINDER study (www.biofinder.se), where the research team focuses on the development of optimized diagnostic algorithms for early diagnosis, and also studies the consequences of different brain pathologies on cognitive, neurologic and psychiatric symptoms in healthy individuals and patients with dementia and parkinsonian disorders. Recently, the BioFINDER team has shown that tau-PET can differentiate Alzheimer’s from other neurodegenerative diseases (Ossenkoppele et al, JAMA, 2018), and that plasma P-tau is a novel promising blood-based biomarker for early detection of Alzheimer’s disease (Janelidze et al, Nature Medicine, 2020; Palmqvist et al, JAMA, 2020). Besides being responsible for the outpatient ward of the Memory Clinic at Skåne University Hospital, he is also in leading positions of several research networks and he is co-director of the strategic research area of neuroscience at Lund University.

Moderator of 1 Session

LIVE SYMPOSIUM DISCUSSION

LIVE DISCUSSION - IMAGING AND FLUID BIOMARKERS

Date
10.03.2021, Wednesday
Session Time
16:00 - 16:30
Session Icon
Live

Presenter of 3 Presentations

NOVEL FLUID BIOMARKERS FOR ALZHEIMER'S DISEASE

Session Type
SYMPOSIUM
Date
10.03.2021, Wednesday
Session Time
10:00 - 12:00
Room
On Demand Symposia A
Lecture Time
10:15 - 10:30
Session Icon
On-Demand

Abstract

Abstract Body

NOVEL FLUID AND PET IMAGING MARKERS FOR NEURODEGENERATIVE DISEASES

There is need for biomarkers that improve the diagnostic work-up of neurodegenerative diseases, including Alzheimer’s disease (AD), which can be used in both clinical practice and trials. In this talk I will focus on recent advances in blood-based biomarkers, and how these can be combined with other easily accessible and low-cost biomarkers to improve detection of early AD. For example, we have recently shown that combining plasma P-tau with brief cognitive tests of memory and executive function can with high accuracy predict future development of AD in patients with subjective cognitive decline or mild cognitive impairment, which outperformed the baseline clinical assessment of dementia experts. Further, I will discuss steps needed to be taken before blood-based biomarkers can be implemented in clinical practice globally. Finally, there will be a discussion on how blood and PET biomarkers can improve clinical trials evaluating disease modifying therapies, when it comes to enrichment of study participants to be included in the trials as well as when measuring relevant effects of the treatments.

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