Oskar Hansson, Sweden
Lund University Clinical Sciences MalmöModerator of 1 Session
Presenter of 3 Presentations
NOVEL FLUID BIOMARKERS FOR ALZHEIMER'S DISEASE
Abstract
Abstract Body
NOVEL FLUID AND PET IMAGING MARKERS FOR NEURODEGENERATIVE DISEASES
There is need for biomarkers that improve the diagnostic work-up of neurodegenerative diseases, including Alzheimer’s disease (AD), which can be used in both clinical practice and trials. In this talk I will focus on recent advances in blood-based biomarkers, and how these can be combined with other easily accessible and low-cost biomarkers to improve detection of early AD. For example, we have recently shown that combining plasma P-tau with brief cognitive tests of memory and executive function can with high accuracy predict future development of AD in patients with subjective cognitive decline or mild cognitive impairment, which outperformed the baseline clinical assessment of dementia experts. Further, I will discuss steps needed to be taken before blood-based biomarkers can be implemented in clinical practice globally. Finally, there will be a discussion on how blood and PET biomarkers can improve clinical trials evaluating disease modifying therapies, when it comes to enrichment of study participants to be included in the trials as well as when measuring relevant effects of the treatments.