James E. Galvin, United States of America
University of Miami Miller School of Medicine NeurologyAuthor Of 2 Presentations
DESIGNING DEMENTIA PREVENTION STUDIES: USING PROXY BIOMARKERS TO IDENTIFY AT-RISK INDIVIDUALS
Abstract
Abstract Body
Aims: The prevention of Alzheimer Disease and Related Dementias (ADRD) may be possible through multimodal interventions that combine lifestyle modification, risk reduction, health promotion, and co-morbidity management using precision medicine approaches. A driving factor in ADRD research is the search for markers of amyloid and tau deposition, however up to 40% of ADRD attributable risk may be explained by other factors and pathologies. We have reported novel non-cognitive prodromal predictors of dementia including gait and mobility impairment, sarcopenia, slowed psychomotor performance, declining physical functionality, and depression.
Methods: In a study of 400 older adults (age 75.3+9.2y; 46.9% female, 50.1% positive family history, 64.6% subjective complaints, 38.1% ApoE 4 carriers) using a comprehensive deep-phenotype evaluation to explore non-MRI/PET/CSF biomarkers to test proxy biomarkers of at-risk individuals compared with healthy controls. These proxy markers include computerized gait analyses, optical coherence tomography, dietary patterns, and serum measures of pathology
Results: Individuals at-risk for ADRD and those with mild cognitive impairment show declining gait velocity on dual cognitive-motor tasks, thinning of the retinal nerve cell layers, poorer MIND diet scores, lower “dosages” of physical and cognitive activity participation, and higher vascular risk scores measured with a modified CAIDE score compared with healthy controls. Finally, plasma ADRD biomarkers may discriminate healthy controls from individuals with pre-clinical ADRD.
Conclusions: Efforts to prevent cognitive decline may be enhanced by examining proxy biomarkers of neurodegenerative disease that are less expensive, less invasive and more accessible. Incorporating these findings into multimodal interventions may offer novel approaches to preventing ADRD.
LIVE DISCUSSION
Presenter of 4 Presentations
LIVE DISCUSSION
- Sakshi Sardar, United States of America
- Dimitris Gatsios, Greece
- James E. Galvin, United States of America
- Pierre-Emmanuel Poulet, France
- Saikal B. Ismailova, Russian Federation
- Alejandro Schuler, United States of America
- Benjamin F. Cornish, Canada
- Pascale Bouchard Cannon, Singapore
- Teresa Arroyo Gallego, Spain
DESIGNING DEMENTIA PREVENTION STUDIES: USING PROXY BIOMARKERS TO IDENTIFY AT-RISK INDIVIDUALS
Abstract
Abstract Body
Aims: The prevention of Alzheimer Disease and Related Dementias (ADRD) may be possible through multimodal interventions that combine lifestyle modification, risk reduction, health promotion, and co-morbidity management using precision medicine approaches. A driving factor in ADRD research is the search for markers of amyloid and tau deposition, however up to 40% of ADRD attributable risk may be explained by other factors and pathologies. We have reported novel non-cognitive prodromal predictors of dementia including gait and mobility impairment, sarcopenia, slowed psychomotor performance, declining physical functionality, and depression.
Methods: In a study of 400 older adults (age 75.3+9.2y; 46.9% female, 50.1% positive family history, 64.6% subjective complaints, 38.1% ApoE 4 carriers) using a comprehensive deep-phenotype evaluation to explore non-MRI/PET/CSF biomarkers to test proxy biomarkers of at-risk individuals compared with healthy controls. These proxy markers include computerized gait analyses, optical coherence tomography, dietary patterns, and serum measures of pathology
Results: Individuals at-risk for ADRD and those with mild cognitive impairment show declining gait velocity on dual cognitive-motor tasks, thinning of the retinal nerve cell layers, poorer MIND diet scores, lower “dosages” of physical and cognitive activity participation, and higher vascular risk scores measured with a modified CAIDE score compared with healthy controls. Finally, plasma ADRD biomarkers may discriminate healthy controls from individuals with pre-clinical ADRD.
Conclusions: Efforts to prevent cognitive decline may be enhanced by examining proxy biomarkers of neurodegenerative disease that are less expensive, less invasive and more accessible. Incorporating these findings into multimodal interventions may offer novel approaches to preventing ADRD.
LIVE DISCUSSION
FORUM SPEAKERS
Moderator of 1 Session