Surenjav Chimed (Mongolia)
Sor clinic
Department of Cardiology

Presenter of 2 Presentations

 Congress Calendar

Young Investigator Awards

Session Name
1550 - ONSITE AND LIVE STREAMED SESSION - Plenary 03: Presentation of Awards and Late Breaking trials (ID 375)
Session Type
Plenary Session
Date
Fri, 28.10.2022
Session Time
13:30 - 15:00
Room
Hall 406
Presenter
Lecture Time
14:00 - 14:07

LEFT ATRIAL FUNCTIONAL REMODELING AND LONG-TERM RISK OF ISCHEMIC STROKE IN POST-STEMI PATIENTS

Session Name
0510 - FREE COMMUNICATIONS 02: CARDIAC ISSUES (ID 244)
Session Type
Clinical Manifestations
Date
Wed, 26.10.2022
Session Time
08:00 - 09:30
Room
Room 331
Presenter
Lecture Time
08:00 - 08:10

Abstract

Background and Aims

Patients with ST-segment elevation myocardial infarction (STEMI) have increased risk of ischemic stroke. In this study, we investigated the association between left atrial (LA) functional remodeling pattern and long-term risk of ischemic stroke in post-STEMI patients.

Methods

Speckle-tracking echocardiography derived late systolic strain rate (SRa) was used to evaluate LA function, while LA volume index (LAVi) was used to estimate LA dilatation. Four distinct LA functional remodeling groups were defined: 1) no LA dysfunction and dilatation, 2) LA dysfunctional but no LA dilatation, 3) no LA dysfunction but LA dilated and 4) LA dysfunctional and dilated.

Results

A total of 524 patients were selected (mean age 60±14, male gender 84.7%). During a median follow-up of 27 months (IQR 13; 41), ischemic stroke occurred for 6 patients (1.1%). The SRa 0.5 (s-1) and LAVi 35 ml/m2, represents the values where the hazard ratio (HR) is greater than unity, were chosen as an optimal threshold to define LA functional remodeling groups (Figure 1A and 1B). Analysis of interaction between SRa and LAVi showed that the risk of ischemic stroke was increasing when LA dilatation was accompanied by LA dysfunction (Figure 1C). Those with LA dysfunction accompanied LA dilatation had a significantly lower event-free survival rate (Log-rank p=0.0024) (Figure 1D). The LA functional remodeling group 4 was significantly associated with increased risk of ischemic stroke (HR=13.6, 95% CI 2.26-82.1, p=0.004).

figure_1.jpg

Conclusions

The LA dysfunction accompanied with LA dilatation is significantly associated with increased risk of ischemic stroke in post-STEMI patients.

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