Soumya Krishnamoorthy (India)
Sree Chitra Tirunal Institute for Medical Sciences and Technology
Neurology

Presenter of 2 Presentations

 Congress Calendar

Young Investigator Awards

Session Name
1550 - ONSITE AND LIVE STREAMED SESSION - Plenary 03: Presentation of Awards and Late Breaking trials (ID 375)
Session Type
Plenary Session
Date
Fri, 28.10.2022
Session Time
13:30 - 15:00
Room
Hall 406
Presenter
Lecture Time
14:00 - 14:07

SOLUBLE ST2 IS A PREDICTOR OF POOR FUNCTIONAL OUTCOME IN ACUTE ISCHEMIC STROKE

Session Name
0580 - FREE COMMUNICATIONS 03: PROGNOSIS I (ID 245)
Session Type
Recovery
Date
Wed, 26.10.2022
Session Time
10:00 - 11:30
Room
Nicoll 2-3
Presenter
Lecture Time
10:00 - 10:10

Abstract

Background and Aims

Circulating blood biomarkers involved in the molecular pathways of stroke can help in the prognosis of acute ischemic stroke (AIS). We assessed the predictive values of plasma soluble serum stimulation-2 (sST2), matrix metalloproteinase-9 (MMP-9) and Claudin-5 in AIS across three timepoints.

Methods

Plasma samples of consecutive AIS patients collected at baseline, 12 h and 24 h from stroke onset were assessed using commercially available immunoassays. Stroke severity was assessed using National Institutes of Health Stroke Scale (NIHSS). Functional outcome was assessed at 90 days using modified Rankin Scale (mRS), with scores 3 to 6 categorized as poor outcome. Receiver operating characteristic curves and multivariable logistic regression were conducted to determine the diagnostic accuracy of the test.

Results

We enrolled 108 patients in the study. Mean age of the population was 62.3±11.7 years and 70% were men. Median NIHSS score was 12 (IQR 10). High baseline glucose levels, systolic blood pressure, baseline NIHSS, low ASPECTS (Alberta Stroke Program Early CT Score), and hemorrhagic transformation were associated with poor outcomes. Elevated sST2 at 24 h positively correlated with poor outcome (84.9±105.8 ng/mL;P=0.004) however, no significant association was reported with MMP-9 (P=0.086) and Claudin-5 (P=0.2) although increased expression of the markers was observed at 12 h. Multivariate logistic regression showed that sST2 levels ≥71.8 ng/mL at 24 h, with a specificity of 96.9%, emerged as an independent predictor of poor functional outcome (OR: 6.44, 95% CI: 1.40-46.3;P=0.029).

Conclusions

Elevated sST2 assessed within 24 hours from onset is an independent predictor of short-term functional outcome in AIS.

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