Animesh K. Basnet, Nepal

Patan Academy of Health Sciences Paediatric Research unit

Author Of 2 Presentations

 Conference Calendar

IMPACT OF PNEUMOCOCCAL CONJUGATE VACCINE (PCV-10) ON RADIOLOGICAL PNEUMONIA AT A TERTIARY CARE CENTRE IN NEPAL (ID 514)

Session Name
Vaccines - Impact of Vaccine programs and Serotype Replacement
Presenter
Authors

Abstract

Background

Routine immunization with 10-valent pneumococcal conjugate vaccine (PCV10) was introduced in Kathmandu in 2015 with doses administered at 6 weeks, 10 weeks and 9 months of age. We assessed the impact of PCV10 on the prevalence of radiographic changes in children aged 2 months to 14 years with a clinical diagnosis of pneumonia admitted to Patan Hospital, Kathmandu.

Methods

Digitalized chest radiographs were interpreted using standardized WHO criteria as primary endpoint pneumonia (PEP), other infiltrate or normal, by two specific readers. A third reader arbitrated upon all discordant results.

Results

From March 2014 to December 2018, 1755 children were enrolled, of whom 1692 (96%) had interpretable radiographs. The proportion of children with PEP decreased annually from 84/189 (44%) in 2014 to 105/414 (25%) in 2018 (p<0.001). PEP was associated with age, occurring in 247/1090 (22%) children <2 years of age, in comparison with 120/175 (69%) children ≥5 years of age (p<0.001), and carriage of PCV10 serotypes, occurring in 95/188 (51%) children with PCV10 carriage in comparison with 459/1504 (31%) children with non-PCV10 serotypes or no carriage (p<0.001).

Conclusions

The prevalence of PEP in children hospitalized with pneumonia decreased from 2014 to 2018 in association with the implementation of PCV10 immunization in Kathmandu.

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IMPACT OF THE INTRODUCTION OF THE PNEUMOCOCCAL CONJUGATE VACCINE ON PAEDIATRIC PNEUMONIA CASES IN NEPAL (ID 543)

Session Name
Vaccines - Impact of Vaccine programs and Serotype Replacement
Presenter
Authors