Nathalia María Vanessa Flórez, Colombia
Subsecretaría de Salud Pública, Secretaría Distrital de Salud Laboratorio de Salud Pública, Dirección de Epidemiología, Análisis y Gestión de Políticas de Salud ColectivaPresenter of 1 Presentation
GENOMIC CHARACTERIZATION OF STREPTOCOCCUS PNEUMONIAE SEROTYPE 19A ISOLATES CAUSING INVASIVE PNEUMOCOCCAL DISEASES AMONG CHILDREN AND ELDERLY FROM BOGOTÁ, COLOMBIA (ID 432)
Author Of 2 Presentations
CHARACTERIZATION OF STREPTOCOCCUS PNEUMONIAE SEROTYPE 19A CAUSING INVASIVE PNEUMOCOCCAL DISEASE FROM BOGOTÁ, COLOMBIA (ID 997)
Abstract
Background
Invasive Pneumococcal Disease (IPDs) is a leading cause of morbidity and mortality. In Colombia, the 7-valent pneumococcal conjugate vaccine was introduced in 2006 and replaced in 2011 by 10-valent. However, the number of S.pneumoniae serotype-19A causing IPDs in Bogotá has considerably increased in the last years. Thus, we characterized all S.pneumoniae serotype-19A isolates received from the Public Health Laboratory Network of Bogotá (PHLNB) in 2017, after Pneumococcal Conjugate Vaccine implementation.
Methods
This study was conducted with all S.pneumoniae serotype-19A isolates received in 2017 from PHLNB. Standard laboratory methods were performed for pneumococcal culture. Identification and antimicrobial susceptibility/resistance were done by automated method (VITEK-BioMérieux). Serotyping results (Quellung Reaction) were received by feedback of the Colombian National Institute of Health. Statistical analysis: Excel/SPSS.
Results
In 2017, 227 S.pneumoniae IPD-isolates were received from PHLNB. The most prevalent serotypes were 19A/3/23A/9N/6C/14/35B. Serotype-19A accounted for 20.3% (46/227) of IPD-isolates. Twenty-two (47.8%) children <5 years were affected by this serotype in 2017 with Pneumonia (39.1%) and Sepsis (34.9%). All 46 serotype-19A were susceptible to vancomycin and chloramphenicol, while reduced susceptibility and/or resistance was observed for erythromycin (100%), penicillin (65.2%) and Trimetoprim-Sulfametoxazol (58.7%).
Conclusions
These results evidence the predominant emergency of S.pneumoniae multidrug-resistant serotype-19A, among children <5 years in Bogotá-Colombia.