POPULATION-BASED HUMAN PAPILLOMAVIRUS INFECTION AND GENOTYPE DISTRIBUTION AMONG WOMEN IN RURAL AREAS OF SOUTH CENTRAL ETHIOPIA (ID 166)
Abstract
Introduction
Introduction: In Ethiopia, cervical cancer is the second leading cause of morbidity and mortality from all cancers in women. Persistent infection with Human Papillomaviruses (HPV) plays a key role in the development of cervical intraepithelial neoplasia and invasive cervical cancer. To establish baseline data on the population-based prevalence of HPV infection and genotype distribution, we investigated cervical HPV epidemiology among rural women who attended a trial for HPV-based screening of cervical cancer.
Methods
A population-based study was conducted among rural women aged 30-49 years old in Butajira, south-central Ethiopia. A total of 893 samples were tested for HPV DNA from 1020 screened women. A self-sampling device (Evalyn Brush®, Rovers, The Netherlands) was used to collect a cervico-vaginal sample and HPV presence and genotype was determined using the BSGP5+/6+ PCR with MPG-Luminex read out.
Results
The positivity rate for HPV was 23.2% (177/764). Among the evaluated women in this study, 20.5% and 10.3% were high risk and low risk HPV positive, respectively. Fifty five (7.2%) of the women showed multiple high risk HPV infections. Age-specific prevalence of high- risk HPV infection among the studied women showed that the peak frequency of infection was in the age-group 30-34 years old [58.6% (92/157)] and went down to the 45-49 years old [3.8% (6/157)]. The top five prevalent high- risk HPV genotypes in this study population were HPV16 (57.1%), 35 (20.3%), 52 (15.8%), 31 (14.1%), and 45 (9.6%).
Conclusions
The overall HPV prevalence, high-risk HPV infection and multiple HPV infections were high among the investigated population and HPV16, HPV35, HPV 52, HPV 31, and HPV 45 were the most prevalent genotypes in Butajira district. As a first population-based study in the country, our results can serve as valuable reference to guide nationwide cervical cancer screening and HPV vaccination programs in Ethiopia.
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