DETECTION OF HIGH RISK HUMAN PAPILLOMAVIRUS (HR-HPV) IN PRECANCEROUS LESIONS OF CERVICAL CANCER (ID 176)
Abstract
Introduction
The High risk Human Papillomavirus (HR-HPV) is the etiologic agent of cervical cancer, second female cancer in Algeria. The objective of this work is to carry out a preliminary prospective study for the detection of HR-HPV infections in Tlemcen, where screening is based solely on cytology.
Methods
One hundred and thirty (130) cervical specimens were used in this study. HPV detection was performed by the Cobas® 4800 HPV test in a laboratory of medical analysis “Ibn Sina” (Constantine) using a real-time PCR. This test identifies specifically HPV16 and/or HPV18 types, and detects simultaneously the remaining HR-HPV types.
Results
A percentage of 21.5% represents positive HPV specimens (28/130) with 5 multiple infections (HPV16 associated) and 23 single infections. The rate of infection by HPV16 (alone or combined) was 28.6% (8/28). Risk factors that appear to be related to HPV infection were, in addition to HIV infection, the lack of early and regular screening; where the majority of patients performed their smears for the first time at an advanced age whose principal reason of gynecological consultations was hemorrhage on contact. In addition to abusive use of oral contraception, and early age of marriage.
Conclusions
These preliminary results encourage us to develop a study on a larger sample of patients, including the HPV test. This test will optimize the performance of early screening of this cancer in our population; to define the prevalence of HPV infection and the distribution of different genotypes, which is necessary in the introduction of vaccination.
/thumbnails/0.png)
