A. Gobbi (Milano, IT)
Orthopaedic Arthroscopic Surgery International Sport and MedicinePresenter Of 6 Presentations
Opening Ceremony
General assembly
9.5.1 - Adipose Tissue Vs. Cellular Matrix
13.3.5 - Case Presentation 5
18.1.9 - Long-term Clinical Outcomes of Cartilage Repair in the Knee Using Hyaluronic Acid-based Scaffold with Bone Marrow Aspirate Concentrate.
Abstract
Purpose
To investigate the long-term clinical outcomes of cartilage repair in the knee using a hyaluronic acid-based scaffold seeded with bone marrow aspirate concentrate (HA-BMAC) for the treatment of full-thickness cartilage injury.
Methods and Materials
Patients treated for full-thickness chondral defects in the knee with HA-BMAC were prospectively followed for a mean duration of 10 years (range 6-12 years). Clinical outcomes were examined using patient reported scoring instruments that consisted of the Tegner Activity Scale, the International Knee Documentation Committee (IKDC) Subjective score, the visual analogue scale (VAS), and the Knee Injury and Osteoarthritis Outcome Score (KOOS). Comparative analysis of preoperative and postoperative scores was performed and the effects of patient age, BMI, lesion size, number of treated lesions, and concurrent treatment with associated procedures were examined.
Results
Twenty-seven patients (mean age 48 years) were prospectively evaluated for a mean duration of 10 years (range 6-12 years). All scores were significantly increased at final follow-up (p<0.001). No difference in mean outcome scores were identified after categorization of patients by age, lesion size, treatment of multiple lesions, treatment of multiple knee compartments, and treatment of associated procedures. Rank correlation analysis demonstrated a negative correlation of patient age and final outcome scores of IKDC, Tegner, VAS, and KOOS subsets of Pain, ADL, Sports, and QOL. No association of BMI or lesion size and outcome scores was identified.
Conclusion
Repair of full-thickness cartilage injury in the knee using a hyaluronic acid-based scaffold with activated bone marrow aspirate concentrate provides good to excellent clinical outcomes in large lesions at long-term follow-up. Good clinical outcomes can be expected in patients over 45 years of age, but outcomes may be comparatively more successful in younger patients.
22.0.12 - Surgery Provides Better Outcomes
Moderator Of 6 Sessions
- A. Gobbi (Milano, IT)
- K. Zaslav (Richmond, US)
- E. Kon (Milano, IT)
- C. Lattermann (Boston, US)
- D. Grande (Manhasset, US)
- T. Minas (West Palm Beach, US)
- M. Brittberg (Kungsbacka, SE)
- L. Biant (Manchester, GB)
- B. Cole (Chicago, US)
- R. Decker (San Diego, US)
- A. Getgood (London, CA)
- A. Gomoll (New York, US)
- M. Hurtig (Guelph, CA)
- J. Lane (La Jolla, US)
- B. Mandelbaum (Santa Monica, US)
- S. Marlovits (Vienna, AT)
- R. McCormack (New Westminster, CA)
- S. Nehrer (Krems, AT)
- E. Papacostas (Kalamaria, Thessaloniki, GR)
- S. Sherman (Palo Alto, US)
- L. Vonk (Utrecht, NL)
- W. Bugbee (La Jolla, US)
- A. Gobbi (Milano, IT)
- T. Minas (West Palm Beach, US)
- E. Kon (Milano, IT)
- K. Zaslav (Richmond, US)
- D. Grande (Manhasset, US)
- C. Lattermann (Boston, US)
- B. Cole (Chicago, US)
- R. Decker (San Diego, US)
- A. Getgood (London, CA)
- L. Vonk (Utrecht, NL)
- S. Nehrer (Krems, AT)
- S. Sherman (Palo Alto, US)
- E. Papacostas (Kalamaria, Thessaloniki, GR)
- J. Lane (La Jolla, US)
- W. Bugbee (La Jolla, US)
- M. Brittberg (Kungsbacka, SE)
Meeting Participant of
- T. Minas (West Palm Beach, US)
- A. Gobbi (Milano, IT)
- E. Kon (Milano, IT)
- D. Grande (Manhasset, US)
- C. Lattermann (Boston, US)
- S. Nehrer (Krems, AT)
- M. Cucchiarini (Homburg/Saar, DE)
- C. Erggelet (Zürich, CH)
- B. Mandelbaum (Santa Monica, US)
- M. McNicholas (Liverpool, GB)
- R. Decker (San Diego, US)
- M. Berruto (Milano, IT)
- S. Sherman (Palo Alto, US)
- F. Sciarretta (Rome, IT)
- A. Krych (Rochester, US)
- J. Lane (La Jolla, US)
- W. Bugbee (La Jolla, US)
- S. Marlovits (Vienna, AT)
- M. Brittberg (Kungsbacka, SE)
- B. Cole (Chicago, US)
- K. Zaslav (Richmond, US)
- B. Mandelbaum (Santa Monica, US)
- D. Saris (Rochester, US)
- E. Kon (Milano, IT)
- D. Grande (Manhasset, US)
- C. Erggelet (Zürich, CH)
- C. Lattermann (Boston, US)
- A. Gobbi (Milano, IT)
- M. Brittberg (Kungsbacka, SE)
- S. Sherman (Palo Alto, US)
- J. Farr (Greenwood, US)
- A. Hollander (Liverpool, GB)
- B. Cole (Chicago, US)
- S. Chubinskaya (Chicago, US)
- T. Minas (West Palm Beach, US)
- A. Gobbi (Milano, IT)
- K. Zaslav (Richmond, US)
- E. Kon (Milano, IT)
- C. Lattermann (Boston, US)
- D. Grande (Manhasset, US)
- T. Minas (West Palm Beach, US)
- M. Brittberg (Kungsbacka, SE)
- L. Biant (Manchester, GB)
- B. Cole (Chicago, US)
- R. Decker (San Diego, US)
- A. Getgood (London, CA)
- A. Gomoll (New York, US)
- M. Hurtig (Guelph, CA)
- J. Lane (La Jolla, US)
- B. Mandelbaum (Santa Monica, US)
- S. Marlovits (Vienna, AT)
- R. McCormack (New Westminster, CA)
- S. Nehrer (Krems, AT)
- E. Papacostas (Kalamaria, Thessaloniki, GR)
- S. Sherman (Palo Alto, US)
- L. Vonk (Utrecht, NL)
- W. Bugbee (La Jolla, US)
- A. Gobbi (Milano, IT)
- T. Minas (West Palm Beach, US)
- E. Kon (Milano, IT)
- K. Zaslav (Richmond, US)
- D. Grande (Manhasset, US)
- C. Lattermann (Boston, US)
- B. Cole (Chicago, US)
- R. Decker (San Diego, US)
- A. Getgood (London, CA)
- L. Vonk (Utrecht, NL)
- S. Nehrer (Krems, AT)
- S. Sherman (Palo Alto, US)
- E. Papacostas (Kalamaria, Thessaloniki, GR)
- J. Lane (La Jolla, US)
- W. Bugbee (La Jolla, US)
- M. Brittberg (Kungsbacka, SE)