Betina Børresen (Denmark)
University of Copenhagen
Department of Veterinary Clinical Sciences
Betina Børresen, DVM, PhD, dipl.ECVIM-CA(onco), is an associate professor of veterinary and comparative oncology at Dept. of Veterinary Clinical Sciences, University of Copenhagen. Her main research activities include translational projects involving veterinary cancer patients as models for human cancer. She is currently testing electron FLASH for treating dogs with spontaneous malignant tumors in collaboration with Lund University.

Moderator of 1 Session

 Online Program
FLASH in Pre-Clinical and Clinical Settings

FLASH in Pre-Clinical and Clinical Settings: Pre-clinical Proton Flash Experiments in a Mouse Model and Possible Implications for Clinical Application

Session Type
FLASH in Pre-Clinical and Clinical Settings
Date
02.12.2022
Session Time
13:45 - 14:15
Room
Hall 113-114
Chair(s)

Presenter of 1 Presentation

 Online Program

Validating FLASH Radiotherapy by Treating Dogs with Spontaneous Cancer

Session Type
FLASH in Pre-Clinical and Clinical Settings
Session Name
0580 - FLASH in Pre-Clinical and Clinical Settings : Validating FLASH Radiotherapy by Treating Dogs with Spontaneous Cancer (ID 45)
Date
01.12.2022
Session Time
11:45 - 12:15
Room
Hall 113-114
Presenter
Lecture Time
11:45 - 12:10

Abstract

Abstract Body

A linear accelerator at Skåne University Hospital at Lund University in Sweden was recently converted to allow delivery of FLASH electron radiotherapy (Lempart et al 2019). To validate its use for clinical patients, a collaboration was then established between the radiation physicists in Lund and veterinary oncologists in Copenhagen, Denmark. The focus of this collaboration has been to establish a clinically relevant workflow, to optimize treatment protocols and to determine early and long-term efficacy and safety of FLASH RT in clinical patients. Since then, a total of 28 dogs with 31 malignant tumors have been treated. The information that we have obtained from the relatively few canine cancer patients treated in this project has been extremely valuable and similar knowledge would have been difficult or even impossible to obtain from experimental models. The results published in Konradsson et al 2021 as well as results from other published veterinary FLASH trials (Vozenin et al 2019, Velalopoulou et al 2021, Rohrer Bley et al 2022) will be briefly described, while more recent results from Lund describing long-term efficacy and toxicity of FLASH RT for treating canine oral cancer patients will be the main focus of the presentation.

Lempart M, Blad B, Adrian G, et al. Modifying a clinical linear accelerator for delivery of ultra-high dose rate irradiation. Radiother Oncol. 2019;139:40-45. doi:10.1016/j.radonc.2019.01.031

Konradsson, E, Arendt, M. L, Bastholm Jensen, K et al. (2021). Establishment and Initial Experience of Clinical FLASH Radiotherapy in Canine Cancer Patients. Frontiers in Oncology, 2021;11:1–10. doi: 10.3389/fonc.2021.658004

Vozenin, M. C. et al. The Advantage of FLASH Radiotherapy Confirmed in Mini-pig and Cat-cancer Patients. Clinical Cancer Research 25, 35–42 (2019). doi: 10.1158/1078-0432.CCR-17-3375

Velalopoulou, A. et al. Flash proton radiotherapy spares normal epithelial and mesenchymal tissues while preserving sarcoma response. Cancer Research 81, 4808–4821 (2021). Doi: 10.1158/1078-0432.CCR-17-3375

Rohrer Bley, C. et al. Dose- and Volume-Limiting Late Toxicity of FLASH Radiotherapy in Cats with Squamous Cell Carcinoma of the Nasal Planum and in Mini Pigs. Clinical Cancer Research OF1–OF10 (2022) doi:10.1158/1078-0432.CCR-22-0262.

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