PD083 - IMPACT OF COVID-19 ON ANTIMICROBIAL CONSUMPTION IN HOSPITALIZED CHILDREN (ID 812)
Abstract
Backgrounds:
High rates of paediatric antibiotic consumption in low and middle- income countries have been systematically documented over the years. The aim of this study is to examine the impact of COVID-19 outbreak on the antibiotic use and stewardship practices in children, as data on national and individual hospital antibiotic consumption are sparse.
Methods
This was a retrospective single-center study, that compared the antimicrobial consumption in hospitalized children between two time periods: the first period was before COVID-19 pandemic (January-December 2019) and the second during COVID-19 pandemic (January-December 2020). Antimicrobial consumption was expressed as defined daily dose (DDT) per 100 bed-days and was calculated on a 6-monthly basis.
Results:
Total antibiotic consumption in 2020 (59,8 DDD per 100 bed-days) decreased by 4,4% compared to 2019 (62,6 DDD per 100 bed-days). The number of hospitalizations decreased in 2020 by 31,5%. There was an increase in the use of certain antimicrobials during 2020 (second generation cephalosporins (18,9%), carbapenems (215,8%), piperacillin/tazobactam (12,3%), and glycopeptides (11,5%) while there was a reduction in the use of ampicillin (−63,2%), amoxicillin/clavulanate (-39,1%), third generation cephalosporins (-21,5%), clindamycin (-27,6%) and aminoglycosides (-51,8%). The elevations in the DDT per 100 bed-days of carbapenems, piperacillin/tazobactam and glycopeptides were observed in the pediatric wards (117,9%, 61,1% and 45,3%, respectively) during 2020, but not in the surgical or ICU wards, where the antimicrobial consumption was at the same levels or decreased.
Conclusions/Learning Points:
This study produces novel information on antimicrobial consumption in children during the COVID-19 pandemic. Further analysis linking these observational data to clinical diagnosis and co-morbidities will provide more evidence as to whether this is related to COVID-19 complications or delayed presentation of the unwell child.
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