AS08.b. Bacterial pneumonia

PD087 - ASSOCIATION BETWEEN THE COVID-19 PANDEMIC AND PERTUSSIS IN FRANCE USING MULTIPLE NATIONWIDE DATA SOURCES (ID 953)

Session Name
0320 - Poster Discussion Session 04: COVID Effects (ID 4)
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https://us04web.zoom.us/j/78531046067?pwd=1Xa_57DfjTsoqJ5XEzQe8_LbkkQX_y.1
Availability (Date and Time)
11/05/2022 at 11:10 am
e-Poster Audio MP3

Abstract

Backgrounds:

Interventions to mitigate coronavirus disease 19 (COVID-19) pandemic may impact other respiratory diseases such as pertussis. We aimed to study the course of pertussis in France over an 8-year period and its association with COVID-19 mitigation strategies, using multiple nationwide data sources and regression models.

Methods

We analyzed the number of French pertussis cases between 2013 and 2020, using the PCR test results from nationwide outpatient laboratories (Source 1) and the pediatric network of 41 hospitals (Source 2). We also used the reports of an office-based pediatric national network (Source 3). We conducted a quasi-experimental interrupted time-series analysis, relying on negative binomial regression models. The models accounted for seasonality, long-term cycles, and secular trend, and included a binary variable for the first national lockdown (ordered on March 16, 2021).

Results:

We identified 19,039 cases of pertussis from the three data sources during the study period. There was a significant decrease of pertussis cases following the implementation of mitigation measures, with adjusted incidence rate ratios of 0.102 (95% CI 0.040-0.256) and 0.216 (95% CI 0.071-0.656) for Source 1 and Source 2, respectively. The association was confirmed in Source 3 (median of 1 [IQR 0-2] vs. 0 [IQR 0-0] pertussis cases per month before and after lockdown, respectively, p=0.0048).

Conclusions/Learning Points:

The drastic reduction of outpatient and hospitalized cases of pertussis suggests an impact of COVID-19 mitigation measures and their consequences on pertussis epidemiology. Pertussis vaccination recommendations should be carefully followed, and disease monitoring should be continued to detect any resurgence after relaxation of mitigation measures.

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PD086 - MYCOPLASMA PNEUMONIAE DETECTIONS BEFORE AND DURING THE COVID-19 PANDEMIC: RESULTS OF A GLOBAL SURVEY, 2017–2021 (ID 580)

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