EP210 - URINARY TRACT INFECTIONS AND KIDNEY STONES ASSOCIATION IN CRETAN PEDIATRIC POPULATION (ID 1469)
Abstract
Backgrounds:
Urinary tract infection (UTI) is frequently reported in children with kidney stones. UTI may either complicate pre-existing lithiasis or be directly responsible for stone formation (infection stones). Genitourinary abnormalities additionally predispose to stone formation by promoting stasis of urine and infection. The aim of this study was to investigate UTIs and lithiasis comorbidity in our region.
Methods
All infants and children up to 16 years old diagnosed with lithiasis/nephrocalcinosis from 2007 to 2021 were retrospectively included in the study. Demographic characteristics, incidence of UTI, co-existence of genitourinary abnormalities and recurrence of lithiasis were recorded.
Results:
A total of 73 children with lithiasis/nephrocalcinosis were retrieved. Twenty six (35.6%), 15 boys and 11 girls with a median age of 4.67 years were found with UTI comorbidity and in 14 of them (53.8%) UTI was the initial manifestation of lithiasis. In these 14 patients although E. coli was the commonest pathogen (6/14) non-E.coli organisms prevailed (P.mirabilis, 5, E.faecalis, 2 and E.cloacae, 1). A significant proportion (43.4%) belonged to immigrant population minorities with limited accessibility to healthcare services and nine of them (34.6%) had a positive family history for lithiasis. Six children (23%) were diagnosed with major genitourinary abnormalities (ureteropelvic junction obstruction, neurogenic bladder, solitary kidney, vesicoureteral reflux, posterior urethral valves) and five (19.2.%) were readmitted with recurrent, non-infectious lithiasis.
Conclusions/Learning Points:
Urolithiasis and UTI comorbidity is not unusual among infants and children in our region and is mostly associated with the genetic and social background of the population as well as genitourinary abnormalities. Nevertheless, UTIs concomitant of lithiasis do not tend to recur. Thorough metabolic investigation and detailed information of previous history will contribute to our further understanding of the lithiasis/UTI association.
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