Claire Booth is a Professor in Gene Therapy and Paediatric Immunology at UCL Great Ormond Street Institute of Child Health and Honorary Consultant in Paediatric Immunology and Gene Therapy at Great Ormond Street Hospital, London. She graduated from Guy’s, King’s and St. Thomas’ School of Medicine in 2001 and then trained in Paediatrics, subspecialising in Paediatric Immunology and Immunodeficiency. Dr. Booth also undertook a PhD at UCL developing haematopoietic stem cell gene therapy to treat XLP. Dr. Booth currently works as a clinical academic leading an expanding number of gene therapy clinical trials at Great Ormond Street Hospital, which treats patients with immune deficiencies, and haematological and metabolic disorders. Her pre-clinical research focuses on the development of gene therapy strategies to treat XLP-1 and XIAP deficiency using a conventional lentiviral mediated corrective strategy alongside exploration of novel gene editing techniques to facilitate targeted gene addition in both haematopoietic stem cells and T cells. As an attending physician, Dr. Booth oversees the clinical management of patients with PID, including hematopoietic stem cell transplantation and maintains a strong interest in HLH disorders. She also holds an honorary position at Boston Children’s Hospital/Dana Farber Cancer Institute and Harvard Medical School.