Background and Aims

Hashimoto's encephalopathy (HE) is an extrathyroidal autoimmune brain disorder. The presense of anti-alpha enolase antibodies (ENO1Ab) was detected in cases of HE, thus it may be a key component in the pathogenesis of HE.

The aim of the study was to analyse possible association between ENO1Ab and anti-thyroid autoantibodies, hormones, psychiatric manifestations.

Methods

We studied 117 patients with Hashimoto's thyroiditis (HT). First group of the patients (n=33) had an HT and different psychiatric disorders (PD). Another group (n=84) had an HT without any psychiatric disorders. Anti-thyroid peroxidase antibodies (antiTPO), anti-thyroglobulin antibodies (antiTG), thyroid stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3), prolactin and ENO1Ab were studied.

Results

In the group with HT and PD ENO1Ab were positive in 33,3% in another group-in 12%. The level of antiTPO was increased in both groups. We found significant positive correlations between ENO1Ab and antiTG (r=0,31; p=0,002), prolactin (r=0,39; p<0,001) in general group (n=117). In the group with HT was a positive significant correlations between ENO1Ab and antiTG (r=0,39; p=0,002), prolactin (r=0,29; p=0,034). Positive correlations in general group between ENO1Ab and hallucination (p=0,034), generalized anxiety (p=0,011), delirium (p=0,018), attention deficit (p=0,033) were found.

Conclusions

Positive correlation of ENO1Ab and antiTG Ab, prolactin in HT patients confirms the hypothesis that ENO1Ab can be a kind of non-classical autoantibody secondary to autoimmune responses to Tg in pathogenesis of HT.

ENO1Ab were associated with psychiatric symptoms in general group of patients, but it was not confirmed in each group separately. Thus, this association is smoothed out as psychic symptoms progress and psychosis treatment begins

Background and Aims

The aim was to identify association of psychiatric manifestations and laboratory data in AIT patients.

Methods

We studied 100 patients with AIT. 25% of our patients had an AIT in combination with different psychiatric disorders. We noticed different psychiatric manifestations in both groups. Patients with AIT had phobias (52%) and sleep disorders (52%). Patients with AIT in combination of psychiatric disorder had phobias (44%), generalized anxiety (92%), sleep disturbances (64%), irritability (40%), panic attacks (52%), hallucinations (72%), delirium (80%), depression (32%), attention deficit (44%). We studied such parameters as antiTPO, antiTG, TSH, FT3, FT4, prolactin and ANA.

Results

We found significant correlations between low level of FT4 and attention deficit (β=-1.9; p=0.003), irritability (β=-2,7;p<0,001), generalized anxiety (β=-1,7;p=0,005), delirium (β=-3,0,p<0,001), hallucinations (β=-1,9;p=0,003), sleep disturbances (β=-1,6;p=0,029). A significant correlation was found between high level of TSH and attention deficit (β=2,5;p=0,009), panic attacks (β=2,5;p=0,009), irritability (β=3,7;p=0,001), delirium (β=3,0;p=0,003). Between high level of antiTPO and attention deficit (β=0,7;p=0,003), panic attacks (β=0,5;p=0,01), irritability (β=0,5;p=0,017), generalized anxiety (β=0,7;p<0,001), depression (β=0,5;p=0,015), delirium (β=0,8;p<0,001) a significant correlation was also detected. There was a significant correlation between high level of prolactin and sleep disturbances (β=1,1;p=0,028), generalized anxiety (β=3,1;p<0,001), depression (β=1,5;p=0,049), delirium (β=2,7;p<0,001). Thus we have detected that correlations between sleep disturbances, phobias and the levels of FT4 and prolactin are significant regardless of the presence of psychiatric disorder.

Conclusions

Several immuno-endocrine parameters significantly correlated to psychic symptoms . The same time correlations between sleep disturbances, phobias and the levels of FT4 and prolactin didn’t depend on the presence of psychiatric disorder.