AIT AND PSYCHIATRIC DISORDERS- IS THERE ANYTHING COMMON?
- Polina Sobolevskaia, Russian Federation
Abstract
Background and Aims
The aim was to identify association of psychiatric manifestations and laboratory data in AIT patients.
Methods
We studied 100 patients with AIT. 25% of our patients had an AIT in combination with different psychiatric disorders. We noticed different psychiatric manifestations in both groups. Patients with AIT had phobias (52%) and sleep disorders (52%). Patients with AIT in combination of psychiatric disorder had phobias (44%), generalized anxiety (92%), sleep disturbances (64%), irritability (40%), panic attacks (52%), hallucinations (72%), delirium (80%), depression (32%), attention deficit (44%). We studied such parameters as antiTPO, antiTG, TSH, FT3, FT4, prolactin and ANA.
Results
We found significant correlations between low level of FT4 and attention deficit (β=-1.9; p=0.003), irritability (β=-2,7;p<0,001), generalized anxiety (β=-1,7;p=0,005), delirium (β=-3,0,p<0,001), hallucinations (β=-1,9;p=0,003), sleep disturbances (β=-1,6;p=0,029). A significant correlation was found between high level of TSH and attention deficit (β=2,5;p=0,009), panic attacks (β=2,5;p=0,009), irritability (β=3,7;p=0,001), delirium (β=3,0;p=0,003). Between high level of antiTPO and attention deficit (β=0,7;p=0,003), panic attacks (β=0,5;p=0,01), irritability (β=0,5;p=0,017), generalized anxiety (β=0,7;p<0,001), depression (β=0,5;p=0,015), delirium (β=0,8;p<0,001) a significant correlation was also detected. There was a significant correlation between high level of prolactin and sleep disturbances (β=1,1;p=0,028), generalized anxiety (β=3,1;p<0,001), depression (β=1,5;p=0,049), delirium (β=2,7;p<0,001). Thus we have detected that correlations between sleep disturbances, phobias and the levels of FT4 and prolactin are significant regardless of the presence of psychiatric disorder.
Conclusions
Several immuno-endocrine parameters significantly correlated to psychic symptoms . The same time correlations between sleep disturbances, phobias and the levels of FT4 and prolactin didn’t depend on the presence of psychiatric disorder.