Victor Gurevich, Russian Federation

Saint-Petersburg State University Medical faculty, Center of Atherosclerosis
Current position: The Head of Department of Atherosclerosis in Saint Petersburg State University, Medical Faculty; Professor of Internal medicine and Cardiology Chair in North-Western State Medical University n. a. I.I. Mechnikov; the Head of the Center of Atherosclerosis and Lipid Disorders in Sokolov’s Hospital, Saint-Petersburg. Education and Training: 1st Saint-Petersburg Medical University n.a. I.P. Pavlov (MD, 1970), Institute of experimental medicine (PhD, 1973), Saint-Petersburg Research Institute of Cardiology (Dr Med Sci, 1986); 1995 - Visiting professor in Louisville University, Ky, USA Current research and clinical interests: Immune and autoimmune mechanisms of atherogenesis. Monoclonal antibodies in lipid lowering therapy. Principal investigator in many clinical trials. Publications: Co-author of Russian National lipid lowering treatment guidelines, 2007, 2012, 2017, 2020 Co-editor, 2-volume Manual on cardiology, 2008. Co-editor 2-volume Collection of clinical cases in cardiology, 2016. Author and co-author of about 100 original articles in the peer reviewed journals indexed in WoS and Scopus, Hirsh index -16; Mostly cited articles: “ Antioxidative activity of high density lipoproteins in vivo”, Atherosclerosis, 100:13-18, 1993; “Autoimmune nature of influenza atherogenicity”. Ann N Y Acad Sci. 2005; 1050:410-6. Professional Societies Memberships: European Atherosclerosis Society, active member; Russian Atherosclerosis Society, Vice-president; Journal “Atherosclerosis and dyslipidemias”, editorial board member.

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 Conference Calendar

THE RELATIONSHIPS BETWEEN TOLL-LIKE RECEPTOR GENES POLYMORPHISM AND ATHEROGENIC LIPID DISORDERS

Session Name
PS41 - GENETICS AND EPIGENETICS IN AUTOIMMUNITY
Session Type
PARALLEL SESSIONS
Date
31.05.2021, Monday
Session Time
10:00 - 12:00
Room
HALL B
Lecture Time
10:40 - 10:50
Presenter
Session Icon
Pre Recorded

Abstract

Background and Aims

We have recently demonstrated that G allele of the rs4986790 polymorphism (Asp299Gly) of TLR4 Gene (AG genotype) has been associated with decreased development of clinical atherosclerosis in familiar hypercholesterolemia (FH). The aim of the study was to analyze the relationships between TLR4 polymorphism and lipid disorders in FH patients.

Methods

Methods. 67 patients with FH (50 female and 17 male) were involved into the study. Heterozygous FH was diagnosed using the Dutch Lipid Clinic Network criteria including genetic testing. The TLR4 rs4986790 polymorphism was determined by polymerase chain reaction/restriction fragment length polymorphism. Low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) and Lipoprotein (a) levels were measured in all patients.

Results

Results. The presence of АА genotype rs4986790 polymorphism of TLR4 gene was found in 82% of patients with FH while AG genotype was detected in 16,4% of patients. That is, the frequency of AG polymorphism of the TLRs gene in FH is at least threefold exceeds that in the general population. Lipid levels were 6.36+0,27 mmol/l vs 6,40+0,21 mmol/l LDL-C in AA genotype vs AG genotype and 1,75+0,17 mmol/l vs 1,62 mmol/l +0,20 HDL-C in AA genotype vs AG genotype correspondingly. Nevertheless in patients with the AA genotype, the frequency of increased levels of atherogenic Lipoprotein (a) was significantly higher than in patients with the AG genotype (38% and 11%, respectively).

Conclusions

Conclusion. The AG allele of rs4986790 polymorphism of TLR4 Gene could be bound with diminished risk of atherosclerosis via its association with decreased levels of Lipoprotein (a).

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