THE RELATIONSHIPS BETWEEN TOLL-LIKE RECEPTOR GENES POLYMORPHISM AND ATHEROGENIC LIPID DISORDERS
- Victor Gurevich, Russian Federation
Abstract
Background and Aims
We have recently demonstrated that G allele of the rs4986790 polymorphism (Asp299Gly) of TLR4 Gene (AG genotype) has been associated with decreased development of clinical atherosclerosis in familiar hypercholesterolemia (FH). The aim of the study was to analyze the relationships between TLR4 polymorphism and lipid disorders in FH patients.
Methods
Methods. 67 patients with FH (50 female and 17 male) were involved into the study. Heterozygous FH was diagnosed using the Dutch Lipid Clinic Network criteria including genetic testing. The TLR4 rs4986790 polymorphism was determined by polymerase chain reaction/restriction fragment length polymorphism. Low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) and Lipoprotein (a) levels were measured in all patients.
Results
Results. The presence of АА genotype rs4986790 polymorphism of TLR4 gene was found in 82% of patients with FH while AG genotype was detected in 16,4% of patients. That is, the frequency of AG polymorphism of the TLRs gene in FH is at least threefold exceeds that in the general population. Lipid levels were 6.36+0,27 mmol/l vs 6,40+0,21 mmol/l LDL-C in AA genotype vs AG genotype and 1,75+0,17 mmol/l vs 1,62 mmol/l +0,20 HDL-C in AA genotype vs AG genotype correspondingly. Nevertheless in patients with the AA genotype, the frequency of increased levels of atherogenic Lipoprotein (a) was significantly higher than in patients with the AG genotype (38% and 11%, respectively).
Conclusions
Conclusion. The AG allele of rs4986790 polymorphism of TLR4 Gene could be bound with diminished risk of atherosclerosis via its association with decreased levels of Lipoprotein (a).