Andreea Morosanu, Romania
Diamed Obesity SRL DiabetesPresenter of 1 Presentation
PROSPECTIVE EVALUATION OF GLUCOSE RANGES AND NUTRITIONAL STATUS IN PERSONS WITH TYPE 1 AND INSULIN-TREATED TYPE 2 DIABETES
Abstract
Background and Aims
Continuous glucose monitoring(CGM) is currently the most precise evaluation of glucose status.Benefits and improvements of glucose control were shown over time.We investigated the evolution of glucose status in type 1 diabetes(T1D) and insulin-treated type 2 diabetes(ITT2D) persons evaluated by CGM, initially and after three months.
Methods
We assessed 21 persons:13-T1D,8-ITT2D;10 women,3 men,mean age 35.67±16.69 years(11-65),mean diabetes duration 8.48±5.96 years(0-19).Glucose distribution was assessed by number and percent of glucose values(NGV,%GV),area under the curve of glucose values(AUC),mean glucose values(MGV)on glucose domains(<70 mg/dl,>180 mg/dl,70-180 mg/dl,90-130 mg/dl).We measured HbA1c,body weight,body mass index(BMI),abdominal circumference(CA),total daily insulin dose(TDI),total daily carbohydrates intake(TDCH) and we performed CGM,initially and after three months.
Results
HbA1c was reduced significantly(S) from 8.56% to 7,4% and decreased in both T1D and ITT2D groups(S).MGV decreased(close to significance-CS).%GV>180 decreased(S),%GV<70,%GV70-180,%GV90-130 increased non-significantly(NS).Total AUC,decreased(NS);hourlyAUC decreased(CS);AUC>180,decreased(NS);AUC<70,increased(CS);AUC 70-180 and AUC 90-130 increased(NS);%AUC>180 decreased(S) and %AUC 70-180 increased(CS);diurnal AUC and nocturnal AUC decreased(NS);hourly diurnal AUC and hourly nocturnal AUC decreased(CS).TDI,insulin dose per kilogram of body weight and TDCH decreased(NS),body weight and BMI did not differ,AC decreased(NS).In ITT2D,%GV<70 and AUC<70 increased(CS),insulin dose decreased (NS),TDCH increased(S),body weight and AC increased(NS).In T1D,AUC 70-180 increased(S),TDCH decreased(S),body weight and BMI did not differ,AC decreased(S).
Conclusions
Following CGM intervention,more glucose values(%GV) and exposure(AUC) decreased under 180 mg/dl and more evident in T1D.Daily carbohydrate intake and abdonimal circumference decreased in T1D.More hypoglycemic values(<70mg/dl) were observed in ITT2D,although non-significant.Daily carbohydrate intake increased significantly in ITT2D,probably due to increase of hypoglycemia.