Rishi Kumar Nigam, India
Rajiv GandhiCollege, Barkatullah University Pathology & Cl. BiochemistryPresenter of 2 Presentations
CORRELATION OF HBA1C WITH URINARY ACR AND E-GFR IN INDIAN DIABETICS
Abstract
Background and Aims
Prevalence of Diabetes mellitus (DM)has reached epidemic proportions globally of which developing countries like India are likely to bear maximum burnt in 21st century, Diabetic nephropathy is a chronic micro vascular complication , leading to end stage renal disease (ESRD). Control of DM is monitored by HbA1c. There are two important early markers to asses renal impairment , glomerular filtration rate (GFR) & microalbuminuria . Microalbuminria is better reflected by spot urine albumin-creatinine ratio (Urinary ACR) and estimated GFR can be calculated by equations .Objective of the study was to evaluate the association of HbA1c with urinary ACR and eGFR in Type 2DM. patients.
Methods
A cross sectional study carried out in the department of Pathology and Clinical biochemistry of Rajeev Gandhi College, including 50 known type 2 DM patients of 40-75 years age were evaluated dividing them on the basis of HbA1c (<8%,>8%), duration of DM (>5 years, <5 years), Blood Glucose, Serum Creatinine, Urinary Albumin & Creatinine were estimated. eGFR and urinary ACR were calculated. Results were expressed as mean ± SD. Data were analyzed with SPSS. Pearson’s correlation tests were performed to assess level of significance.
Results
Study shows that, HbA1c has significant positive correlation with Urinary ACR & with S. Creatinine and there is significant negative correlation of HbA1c with eGFR more with HbA1c >8%. Duration of DM has less significant correlation with renal functional parameters.
Conclusions
Raised HbA1c is associated with urinary ACR. ACR should be estimated in monitoring risk assessment of Type 2DM in patients with raised HbA1c.
A BIOCHEMICAL AND SOCIO-BEHAVIORAL ANALYSIS OF NUTRITIONAL STATUS OF ELDERLY INDIAN DIABETICS
Abstract
Background and Aims
Prevalence of Diabetes mellitus has reached epidemic proportions globally of which developing countries are likely to bear maximum burnt in 21st century. Along with this, elderly population is gaining very sizable proportion and is going to increase in future. Aging causes physical, physiological, and psychological changes leading to changed needs and the diabetes in conjunction adds to various health problems. Elderly diabetics are also likely prone to frailty. Looking at their specialized nutritional and psychosocial needs, the study of elderly diabetics was done to assess their nutritional status and psychosocial behavior.
Methods
For a case controlled study ,45 diabetic elderly (age<60 years) of both the genders was selected from various areas through geriatric health camps held in Bhopal city of India along with control group of 45 non-diabetic elderly. To compare nutritional health assessment, mini nutritional assessment chart and anthropometrics measures like BMI, and waist circumference, clinical frailty scale, were used. Biochemical parameters like serum protein, cholesterol and HbA1c were assessed and correlated with anthropometric and behavioral measures (Geriatric Depression Scale) in both the groups.
Results
Results analyzed in line with Indian lifestyle and dietary habits shows that 77% of diabetic elderly have high waist circumference and 63% are overweight or obese ,82% suffers from hypercholesterolemia quite higher to control group. 65% of Diabetics are. mild to moderately frail. A positive correlation with HbA1c and depression score (r= -988)was found.
Conclusions
Elderly Indian diabetics are having central obesity with higher cholesterol levels and are likely to be more prone to frailty and depression.