Prevalence of Diabetes mellitus (DM)has reached epidemic proportions globally of which developing countries like India are likely to bear maximum burnt in 21st century, Diabetic nephropathy is a chronic micro vascular complication , leading to end stage renal disease (ESRD). Control of DM is monitored by HbA1c. There are two important early markers to asses renal impairment , glomerular filtration rate (GFR) & microalbuminuria . Microalbuminria is better reflected by spot urine albumin-creatinine ratio (Urinary ACR) and estimated GFR can be calculated by equations .Objective of the study was to evaluate the association of HbA1c with urinary ACR and eGFR in Type 2DM. patients.
A cross sectional study carried out in the department of Pathology and Clinical biochemistry of Rajeev Gandhi College, including 50 known type 2 DM patients of 40-75 years age were evaluated dividing them on the basis of HbA1c (<8%,>8%), duration of DM (>5 years, <5 years), Blood Glucose, Serum Creatinine, Urinary Albumin & Creatinine were estimated. eGFR and urinary ACR were calculated. Results were expressed as mean ± SD. Data were analyzed with SPSS. Pearson’s correlation tests were performed to assess level of significance.
Study shows that, HbA1c has significant positive correlation with Urinary ACR & with S. Creatinine and there is significant negative correlation of HbA1c with eGFR more with HbA1c >8%. Duration of DM has less significant correlation with renal functional parameters.
Raised HbA1c is associated with urinary ACR. ACR should be estimated in monitoring risk assessment of Type 2DM in patients with raised HbA1c.